Protein Alignment Atg18a and Wipi1

DIOPT Version :10

• Sequence 1: NP_001261565.1
• Gene: Atg18a / 38913
• FlyBaseID: FBgn0035850
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_666052.1
• Gene: Wipi1 / 52639
• MGIID: 1261864
• Length: 446
• Species: Mus musculus
• Alignment Length: 438
• Identity: 190/438 - (43%)
• Similarity: 274/438 - (62%)
• Gaps: 55/438 - (12%)

  Fly     6 GRTDVDAGEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKS-DELFLIERLFESSLV 69
            ||  |:|.....:|||:.||||:.|..||.|:||.||:. ||:::.:.. .:::::||||.||||
Mouse    11 GR--VEAALSCFSFNQDCTSLAIGTKAGYKLFSLSSVEQ-LDQVHGSNEIPDVYIVERLFSSSLV 72

  Fly    70 AIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRD 134
            .:||...||::.|.||||.:|||||||::.||:::|||:||:||||||:|||||:|||::.|:.|
Mouse    73 VVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLD 137

  Fly   135 TPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIA 199
            .|.||.||||||.:..:.|||||||.:.||:.::|..:|.....|.||:..|||:.|:.||:::|
Mouse   138 IPSNPTGLCALSINHSNSYLAYPGSQSTGEIVLYDGNSLKTVCTIAAHEGTLAAITFNSSGSKLA 202

  Fly   200 TASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRLDRSATE 264
            :|||:||||||||..:|.:|:|.|||:||.|:|.||.||..:::|.:||||||||||:::.....
Mouse   203 SASEKGTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEHLTDS 267

  Fly   265 TAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTLPEAGVRRMCAIATIQ 329
            ..|      ....|.||....|::  .|:|||.||:|:.:|.||||:..|..:|.:.:|.::|||
Mouse   268 RPE------EPSTWSGYMGKMFMA--ATNYLPAQVSDMMNQDRAFATGRLNFSGQKNICTLSTIQ 324

  Fly   330 KQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDL----RLEDHYAMDIKVDSPQTLGLNSGVSI 390
            |..|||:||.||:||:|::...:|.||.|||.|.|    ..|::...|::
Mouse   325 KLPRLLVASSDGHLYIYNLDPQDGGECVLIKTHSLLSSGTTEENKENDLR--------------- 374

  Fly   391 GGAAGVPPSSASAAGAGTGGSGGDGKSAVSVTGGVDKPSSSYASAVKG 438
               ..:|||.|:.                     |.:||:|.||.|.|
Mouse   375 ---PSLPPSYAAT---------------------VARPSTSAASTVPG 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	23..269	CDD:475233	128/246 (52%)
		WD40 repeat	143..180	CDD:293791	15/36 (42%)
		WD40	<160..>271	CDD:441893	51/110 (46%)
		WD40 repeat	186..231	CDD:293791	26/44 (59%)
		WD40 repeat	232..258	CDD:293791	16/25 (64%)
Wipi1	NP_666052.1	WD40	<88..262	CDD:475233	99/173 (57%)
		Nuclear receptor interaction. /evidence=ECO:0000250|UniProtKB:Q5MNZ9	131..136		1/4 (25%)
		WD40 repeat	144..184	CDD:293791	18/39 (46%)
		WD 1	184..224		22/39 (56%)
		WD40 repeat	189..226	CDD:293791	21/36 (58%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	225..228		1/2 (50%)
		WD 2	230..269		19/38 (50%)
		WD40 repeat	236..265	CDD:293791	15/28 (54%)
		WD40 repeat	272..312	CDD:293791	17/41 (41%)
		WD 3	312..351		17/38 (45%)
		WD40 repeat	320..358	CDD:293791	20/37 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..406		7/13 (54%)