DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg18a and Wipi1

DIOPT Version :9

Sequence 1:NP_001261565.1 Gene:Atg18a / 38913 FlyBaseID:FBgn0035850 Length:447 Species:Drosophila melanogaster
Sequence 2:NP_666052.1 Gene:Wipi1 / 52639 MGIID:1261864 Length:446 Species:Mus musculus


Alignment Length:438 Identity:190/438 - (43%)
Similarity:274/438 - (62%) Gaps:55/438 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GRTDVDAGEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKS-DELFLIERLFESSLV 69
            ||  |:|.....:|||:.||||:.|..||.|:||.||:. ||:::.:.. .:::::||||.||||
Mouse    11 GR--VEAALSCFSFNQDCTSLAIGTKAGYKLFSLSSVEQ-LDQVHGSNEIPDVYIVERLFSSSLV 72

  Fly    70 AIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIRD 134
            .:||...||::.|.||||.:|||||||::.||:::|||:||:||||||:|||||:|||::.|:.|
Mouse    73 VVVSHTKPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLD 137

  Fly   135 TPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGTEIA 199
            .|.||.||||||.:..:.|||||||.:.||:.::|..:|.....|.||:..|||:.|:.||:::|
Mouse   138 IPSNPTGLCALSINHSNSYLAYPGSQSTGEIVLYDGNSLKTVCTIAAHEGTLAAITFNSSGSKLA 202

  Fly   200 TASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRLDRSATE 264
            :|||:||||||||..:|.:|:|.|||:||.|:|.||.||..:::|.:||||||||||:::.....
Mouse   203 SASEKGTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEHLTDS 267

  Fly   265 TAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTLPEAGVRRMCAIATIQ 329
            ..|      ....|.||....|::  .|:|||.||:|:.:|.||||:..|..:|.:.:|.::|||
Mouse   268 RPE------EPSTWSGYMGKMFMA--ATNYLPAQVSDMMNQDRAFATGRLNFSGQKNICTLSTIQ 324

  Fly   330 KQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDL----RLEDHYAMDIKVDSPQTLGLNSGVSI 390
            |..|||:||.||:||:|::...:|.||.|||.|.|    ..|::...|::               
Mouse   325 KLPRLLVASSDGHLYIYNLDPQDGGECVLIKTHSLLSSGTTEENKENDLR--------------- 374

  Fly   391 GGAAGVPPSSASAAGAGTGGSGGDGKSAVSVTGGVDKPSSSYASAVKG 438
               ..:|||.|:.                     |.:||:|.||.|.|
Mouse   375 ---PSLPPSYAAT---------------------VARPSTSAASTVPG 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg18aNP_001261565.1 WD40 <15..278 CDD:225201 131/263 (50%)
WD40 23..269 CDD:295369 128/246 (52%)
WD40 repeat 143..180 CDD:293791 15/36 (42%)
WD40 repeat 186..231 CDD:293791 26/44 (59%)
WD40 repeat 232..258 CDD:293791 16/25 (64%)
Wipi1NP_666052.1 WD40 <88..262 CDD:295369 99/173 (57%)
WD40 <100..265 CDD:225201 89/164 (54%)
Nuclear receptor interaction. /evidence=ECO:0000250 131..136 1/4 (25%)
WD40 repeat 144..184 CDD:293791 18/39 (46%)
WD 1 184..224 22/39 (56%)
WD40 repeat 189..226 CDD:293791 21/36 (58%)
WD 2 230..269 19/38 (50%)
WD40 repeat 236..265 CDD:293791 15/28 (54%)
WD40 repeat 272..312 CDD:293791 17/41 (41%)
WD 3 312..351 17/38 (45%)
WD40 repeat 320..358 CDD:293791 20/37 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..406 7/13 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831988
Domainoid 1 1.000 423 1.000 Domainoid score I624
eggNOG 1 0.900 - - E1_KOG2110
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 423 1.000 Inparanoid score I1756
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54442
OrthoDB 1 1.010 - - D1216824at2759
OrthoFinder 1 1.000 - - FOG0001466
OrthoInspector 1 1.000 - - otm43483
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11227
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R106
SonicParanoid 1 1.000 - - X1186
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.900

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