Protein Alignment Atg18a and wdr45b

DIOPT Version :10

• Sequence 1: NP_001261565.1
• Gene: Atg18a / 38913
• FlyBaseID: FBgn0035850
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_956534.2
• Gene: wdr45b / 393210
• ZFINID: ZDB-GENE-040426-863
• Length: 344
• Species: Danio rerio
• Alignment Length: 392
• Identity: 106/392 - (27%)
• Similarity: 174/392 - (44%)
• Gaps: 70/392 - (17%)

  Fly     2 MSLLGRTDVDAGEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFL------I 60
            |:||.......|.::..|||:....|.....|:.:|:...:..        |..:.||      :
Zfish     1 MNLLPSNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKE--------KEKQEFLEGGVGHV 57

  Fly    61 ERLFESSLVAIVS-----QRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESL-- 118
            |.||..:.:|:|.     :..|.|:.:....|:..:....::..:.||||.|:|::|.|:..:
Zfish    58 EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKV 122

  Fly   119 --YIHNIQDMKVVHTIRDTPC-NPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTM-I 179
              :.||...:.|..|     | ||:|||.|..:|.:..||:| :..:|.|||.|..|.....: |
Zfish   123 FTFTHNPHQLHVFET-----CYNPKGLCVLCPNSNNSLLAFP-ATHSGHVQIVDLANTEKPPVDI 181

  Fly   180 PAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYL 244
            |||:..|..:..:..||.||||||:||:||:|.:..|..:.||||| .:..:|..::|:..|..:
Zfish   182 PAHEGVLCCITLNLQGTRIATASEKGTLIRIFDTSAGQLIQELRRG-SQTANIYCINFNQDASLI 245

  Fly   245 VSSSNTETVHIFRLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAF 309
            ..||:..|||||..:       :...:|||             |....|:||    ..||...:|
Zfish   246 CVSSDHGTVHIFAAE-------DPKRNKQS-------------SLASASFLP----KYFSSKWSF 286

  Fly   310 ASVTLPEAGVRRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDI 374
            :...:| :|...:||..|....:..:.|....|.::::    ...||.         .|.||..:
Zfish   287 SKFQVP-SGSPCVCAFGTEPNAVIAICADGSYYKFLFN----PKGECS---------RDVYAQFL 337

  Fly   375 KV 376
            ::
Zfish   338 EM 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	23..269	CDD:475233	77/262 (29%)
		WD40 repeat	143..180	CDD:293791	12/37 (32%)
		WD40	<160..>271	CDD:441893	40/111 (36%)
		WD40 repeat	186..231	CDD:293791	20/44 (45%)
		WD40 repeat	232..258	CDD:293791	10/25 (40%)
wdr45b	NP_956534.2	WD40	34..257	CDD:475233	73/237 (31%)
		WD40 repeat	102..126	CDD:293791	8/23 (35%)
		WD40 repeat	145..183	CDD:293791	13/38 (34%)
		WD 1	183..223		17/39 (44%)
		WD40 repeat	188..225	CDD:293791	16/36 (44%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	224..227		2/2 (100%)
		WD 2	228..267		10/45 (22%)
		WD40 repeat	234..267	CDD:293791	9/39 (23%)