DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18a and wdr45

DIOPT Version :9

Sequence 1:	NP_001261565.1	Gene:	Atg18a / 38913	FlyBaseID:	FBgn0035850	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_956525.1	Gene:	wdr45 / 393200	ZFINID:	ZDB-GENE-040426-990	Length:	358	Species:	Danio rerio

Alignment Length:	386	Identity:	97/386 - (25%)
Similarity:	170/386 - (44%)	Gaps:	69/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VNFNQNITSLAVATSGGYSLYSLGSVDSTLDK--IYHTKSDELFLIERLFESSLVAIVSQRAPRK 79
            :.|||:.:....|...|..:|   :|:..::|  :.|.:...:.|...|..|:|:|:|......|
Zfish    10 LQFNQDQSCFCCAMETGVRIY---NVEPLMEKGHLDHEQVGSIALCSMLHRSNLLAVVGGGVNPK 71

  Fly    80 L-----------KVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHTIR 133
            .           :.....|...:..:::...:|||::..:::|:.|:..:|:::..|..|.....
Zfish    72 FSEISVLIWDDAREVRDPKDKLVLEFTFTKPVLAVRMRHDKIIIILKNRIYVYSFPDNPVKLFEF 136

  Fly   134 DTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKT-----MIPAHDTPLAALAFSP 193
            ||..||:|||.|..|.|...|.:||. ..|.:|:.|..|....|     .|.||.:.:|.||.:.
Zfish   137 DTRDNPKGLCDLCPSLEKQLLVFPGH-KCGSLQLVDLSNTKPGTSSAPFTINAHQSEIACLALNQ 200

  Fly   194 SGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIF-- 256
            .|:.:|:||.:||:||:|.:....:|.|||||... .::..::||..:.:|.:||:..|||||
Zfish   201 PGSVVASASRKGTLIRLFDTTTRDKLVELRRGTDP-ATLYCINFSHDSSFLCASSDKGTVHIFAL 264

  Fly   257 ---RLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVTLPEAG 318
               :|:|.:.....|.                 :...:..|:.:|        .:.|:.|:| |.
Zfish   265 KDTKLNRRSALARVGK-----------------VGPVIGQYVDSQ--------WSLANFTVP-AE 303

  Fly   319 VRRMCAIA-TIQKQLRLLIA-SQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDIKVD 377
            ...:||.. ...|.:..:|| ..||..:.| :.|.:| .|           :..|.|:.:|
Zfish   304 CACICAFGKNTSKNVNSVIAICVDGTFHKY-VFTPDG-NC-----------NREAFDVYLD 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	77/283 (27%)
		WD40	23..269	CDD:295369	73/268 (27%)
		WD40 repeat	143..180	CDD:293791	12/41 (29%)
		WD40 repeat	186..231	CDD:293791	18/44 (41%)
		WD40 repeat	232..258	CDD:293791	10/30 (33%)
wdr45	NP_956525.1	WD 1	2..40		8/32 (25%)
		WD40	6..262	CDD:295369	72/256 (28%)
		WD40	119..>273	CDD:225201	54/155 (35%)
		WD 2	188..228		15/39 (38%)
		WD40 repeat	194..231	CDD:293791	15/36 (42%)
		WD 3	233..272		11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950