Protein Alignment Atg18a and Atg18a

DIOPT Version :10

• Sequence 1: NP_001261565.1
• Gene: Atg18a / 38913
• FlyBaseID: FBgn0035850
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: XP_001688752.1
• Gene: Atg18a / 1276577
• VectorBaseID: AGAMI1_002169
• Length: 419
• Species: Anopheles gambiae
• Alignment Length: 424
• Identity: 275/424 - (64%)
• Similarity: 331/424 - (78%)
• Gaps: 23/424 - (5%)

  Fly     2 MSLLGRTDVDAGEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDKIYHTKSDELFLIERLFES 66
            ||||.|||:|||..||||||:.:||||.:..||||:||.||||.||:||.:.::::.|:||||.|
Mosquito     1 MSLLARTDIDAGGFFVNFNQDCSSLAVGSKNGYSLFSLNSVDSNLDQIYTSLAEDICLVERLFSS 65

  Fly    67 SLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKVVHT 131
            ||||:||..||||||||||||.:|||||||:||||||||||.||:||||||||||||:|||||||
Mosquito    66 SLVAVVSLNAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRSRLVVCLEESLYIHNIRDMKVVHT 130

  Fly   132 IRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKTMIPAHDTPLAALAFSPSGT 196
            |||||.|..|||||:|.|:|||||||||.|.||||||||:|||||.||||||:||||:|||..||
Mosquito   131 IRDTPPNKTGLCALASDSDHCYLAYPGSATVGEVQIFDAVNLHAKIMIPAHDSPLAAIAFSQIGT 195

  Fly   197 EIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETVHIFRLDRS 261
            |||||||:||||||||..|||:|||.|||:||||||.||:||||::||..||||||||:|:|:|.
Mosquito   196 EIATASEKGTVIRVFSVSDGSKLFEFRRGVKRCVSIASLAFSTCSKYLCCSSNTETVHVFKLERV 260

  Fly   262 ATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSY--LPTQVTDVFSQGRAFASVTLPEAGVRRMCA 324
            :.||.:..|:.::   |.|.     :||..|:|  ||||||||||||||||:..||..|:|..|.
Mosquito   261 SPETNDEQGAGEA---WYGK-----ISKAFTNYLPLPTQVTDVFSQGRAFAAALLPVPGLRHSCV 317

  Fly   325 IATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDIKVDSPQT----LGLN 385
            |.||||.||:|:||||||||||.||| ||.||||||:||||     .:::..:.|:|    :|:.
Mosquito   318 ITTIQKALRMLVASQDGYLYVYQIPT-EGGECQLIKKHDLR-----NIELPPNPPRTESVPIGVP 376

  Fly   386 SGVSIGG---AAGVPPSSASAAGAGTGGSGGDGK 416
            :.|..||   ||.|..::.|:||:|.||..|..:
Mosquito   377 TVVPSGGSSYAATVRGTAGSSAGSGGGGVAGSAE 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	23..269	CDD:475233	182/245 (74%)
		WD40 repeat	143..180	CDD:293791	29/36 (81%)
		WD40	<160..>271	CDD:441893	80/110 (73%)
		WD40 repeat	186..231	CDD:293791	35/44 (80%)
		WD40 repeat	232..258	CDD:293791	18/25 (72%)
Atg18a	XP_001688752.1	WD40	14..258	CDD:475233	184/243 (76%)
		WD40 repeat	14..51	CDD:293791	24/36 (67%)
		WD40 repeat	57..97	CDD:293791	31/39 (79%)
		WD40 repeat	102..134	CDD:293791	28/31 (90%)
		WD40 repeat	142..179	CDD:293791	29/36 (81%)
		WD40	<162..258	CDD:441893	75/95 (79%)
		WD40 repeat	185..222	CDD:293791	29/36 (81%)
		WD40 repeat	229..271	CDD:293791	25/41 (61%)