DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg18a and WDR45

DIOPT Version :9

Sequence 1:	NP_001261565.1	Gene:	Atg18a / 38913	FlyBaseID:	FBgn0035850	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_009006.2	Gene:	WDR45 / 11152	HGNCID:	28912	Length:	361	Species:	Homo sapiens

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	175/391 - (44%)	Gaps:	70/391 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GEVFVNFNQNITSLAVATSGGYSLYSLGSVDSTLDK--IYHTKSDELFLIERLFESSLVAIVSQR 75
            |...:.|||:.:....|...|..:|   :|:..::|  :.|.:...:.|:|.|..|:|:|:|...
Human     8 GVTSLRFNQDQSCFCCAMETGVRIY---NVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGG 69

  Fly    76 APRKLKVCHF------------KKQSEICNYSYANTILAVKLNRERLIVCLEESLYIHNIQDMKV 128
            :..|......            .|:..:..:::...:|:|::..:::::.|:..:|:::..|...
Human    70 SSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPR 134

  Fly   129 VHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHAKT-----MIPAHDTPLAA 188
            .....||..||:|||.|..|.|...|.:||. ..|.:|:.|..:....|     .|.||.:.:|.
Human   135 KLFEFDTRDNPKGLCDLCPSLEKQLLVFPGH-KCGSLQLVDLASTKPGTSSAPFTINAHQSDIAC 198

  Fly   189 LAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTCAEYLVSSSNTETV 253
            ::.:..||.:|:||::||:||:|.:|...:|.|||||... .::..::||..:.:|.:||:..||
Human   199 VSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDP-ATLYCINFSHDSSFLCASSDKGTV 262

  Fly   254 HIF-----RLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQGRAFASVT 313
            |||     ||:|.:.....|.                 :...:..|:.:|        .:.||.|
Human   263 HIFALKDTRLNRRSALARVGK-----------------VGPMIGQYVDSQ--------WSLASFT 302

  Fly   314 LPEAGVRRMCAIA-TIQKQLRLLIA-SQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHYAMDIKV 376
            :| |....:||.. ...|.:..:|| ..||..:.| :.|.:| .|           :..|.|:.:
Human   303 VP-AESACICAFGRNTSKNVNSVIAICVDGTFHKY-VFTPDG-NC-----------NREAFDVYL 353

  Fly   377 D 377
            |
Human   354 D 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg18a	NP_001261565.1	WD40	<15..278	CDD:225201	75/286 (26%)
		WD40	23..269	CDD:295369	71/269 (26%)
		WD40 repeat	143..180	CDD:293791	11/41 (27%)
		WD40 repeat	186..231	CDD:293791	18/44 (41%)
		WD40 repeat	232..258	CDD:293791	10/30 (33%)
WDR45	NP_009006.2	WD 1	1..34		7/28 (25%)
		WD40	8..265	CDD:421866	70/261 (27%)
		WD 3	93..129		5/35 (14%)
		WD 4	134..175		15/41 (37%)
		WD 5	184..223		14/38 (37%)
		WD40 repeat	197..233	CDD:293791	14/35 (40%)
		WD 6	228..267		16/39 (41%)
		WD 7	285..330		12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950