DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and esrra

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001072756.1	Gene:	esrra / 780213	XenbaseID:	XB-GENE-485432	Length:	408	Species:	Xenopus tropicalis

Alignment Length:	432	Identity:	176/432 - (40%)
Similarity:	230/432 - (53%)	Gaps:	65/432 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DSLKGSGTSGGNGGGGGGGTSGG------NATNASAGAGSGSVRDELRRLCLVCGDVASGFHYGV 141
            :|:.....||.:...|.|....|      ...:..:|.|...:....:||||||||||||:||||
Frog    20 ESIGRRSPSGSSDSSGHGPDPPGQRCCRDEEQDDVSGRGKYVLNSIPKRLCLVCGDVASGYHYGV 84

  Fly   142 ASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGR 206
            ||||||||||||||||||||:|||:|||||.||||||||||||.|||.:||||||||||||||||
Frog    85 ASCEACKAFFKRTIQGNIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGR 149

  Fly   207 QKYRRNPVSNSYQTMQLLYQS----NTTSLCDVKILEVLNSY-------EPDALSVQTPPPQVHT 260
            |||:|.|.....|     |.|    ...|...||....:|:.       |||.|.....|
Frog   150 QKYKRRPEGEILQ-----YTSGGPAQQASATVVKKQTPVNAVVSHLLVAEPDKLFAMPDP----- 204

  Fly   261 TSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWAKQIPG 325
                                 ..|:|..           :.:|.|.|:.|:|:|.:|.|||.|||
Frog   205 ---------------------ALPDGYL-----------KSMSTLCDLADREIVIIISWAKNIPG 237

  Fly   326 FIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIA 390
            |..|.|:|||.|||..|.|:|.|.:.|||||:..::.||.|..:||..::....|:.....:.:.
Frog   238 FSSLSLSDQMSLLQSVWMEVLLLGVVFRSLPYEDEVVFAEDFVLDEESSRSARLTDLCSCILHLV 302

  Fly   391 QRMERISPRREEYYLLKALLLANCD-ILLDDQSSLRAFRDTILNSLNDVVYLL-RHSSAVSHQQQ 453
            ::...:...:|||.:||||.|.|.| :.::|..::...||.:..:|::  |.. ||........:
Frog   303 RKYRTLRVEKEEYVMLKALTLTNSDSVHIEDPDAVLRLRDALQEALSE--YESGRHPEEPCRDGK 365

  Fly   454 LLLLLPSLRQ-ADDILRRFWRGIARDEVITMKKLFLEMLEPL 494
            |||.||.||| |..:|:.| ..:..:..:.|.||||||||.:
Frog   366 LLLTLPLLRQTAGRVLQHF-HALREEGAVPMHKLFLEMLEAM 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	80/95 (84%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	81/265 (31%)
esrra	NP_001072756.1	NR_DBD_ERR	64..160	CDD:143544	80/95 (84%)
esrra	NP_001072756.1	NR_LBD_ERR	186..405	CDD:132744	80/258 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2805
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297679at33208
OrthoFinder	1	1.000	-	-		FOG0001624
OrthoInspector	1	1.000	-	-		otm48489
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1027
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070