DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and pgr

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001159807.1	Gene:	pgr / 569575	ZFINID:	ZDB-GENE-990415-214	Length:	617	Species:	Danio rerio

Alignment Length:	400	Identity:	112/400 - (28%)
Similarity:	184/400 - (46%)	Gaps:	64/400 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 RRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCL 188
            :|.|::|||.|||.||||.:|.:||.|||..::|:..|.|...|:|.::|.|||.|.|||.:||.
Zfish   248 QRQCVICGDEASGCHYGVLTCGSCKVFFKTAVEGHHNYLCAGRNDCIVDKIRRKNCPACRLRKCY 312

  Fly   189 LMGMLKEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQT 253
            ..||:..|.::.|. .|.:....:|        .|::||..:.|.|.:.|..|..... ...:|.
Zfish   313 QAGMMLGGRKMKRF-AGLKVMGLSP--------SLMFQSPLSLLTDGQTLSSLPCMSA-MRELQL 367

  Fly   254 PPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIG 318
            .|..:   ||..:          :|..||...    :.|.....|:.:|:.|:.:.:::|:.::.
Zfish   368 SPQMI---SILEN----------IEPQVVYSG----YDNTQPEVPHLLLNSLNRLCERQLLWIVR 415

  Fly   319 WAKQIPGFIDLPLNDQMKLLQVSWAEILTLQL---TFRSLPFNGKLCFATD-VWMDEHLAKECGY 379
            |:|.:|||.:|.:||||.|:|.||..::...|   ||:::. ...|.||.| |..::.|.:
Zfish   416 WSKSLPGFRNLHINDQMTLIQYSWMGLMLFSLGWRTFQNVT-PDYLYFAPDLVLSNDQLRR---- 475

  Fly   380 TEFYYHCVQ---IAQRMERISPRREEYYLLKALLLANCDIL--LDDQSSLRAFRDTILNSLNDVV 439
            :..|..|:.   :.|....:...:||:..:|||:|.|...|  |..|:.....|...:..|:..:
Zfish   476 SPIYDLCLAMQFVPQEFANLQVTKEEFLCMKALMLLNTVPLEGLKSQTQFDEMRQNYICELSKAI 540

  Fly   440 YLLRHSSAVSHQQQL------------------LLLLPSLRQADDILRRFWRGIARDEVIT--MK 484
            . |:....|:..|:.                  |..|.:..|||.:...|...:.  |||.  :.
Zfish   541 Q-LKEKGVVASSQRFYHLTKLMDNMHEIVKKVNLYCLTTFIQADAMKVEFPEMMT--EVIASQLP 602

  Fly   485 KLFLEMLEPL 494
            |:...|::||
Zfish   603 KVLAGMVKPL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	39/92 (42%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	66/284 (23%)
pgr	NP_001159807.1	Na_K-ATPase	<71..>125	CDD:298651
		zinc finger DBD	246..316		33/67 (49%)
		NR_DBD_GR_PR	247..324	CDD:143546	36/75 (48%)
		NR_LBD_PR	370..617	CDD:132759	63/267 (24%)
		LBD	404..567		42/168 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940