DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and nr3c1

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001018547.2	Gene:	nr3c1 / 553740	ZFINID:	ZDB-GENE-050522-503	Length:	746	Species:	Danio rerio

Alignment Length:	511	Identity:	145/511 - (28%)
Similarity:	223/511 - (43%)	Gaps:	106/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GTNMSDG----------VSIL-HIKQEVDTPSASCFSP---SSKSTATQSGTNGLKSSPSVSPER 60
            |:|..:|          .||| :||.|.|:....| :|   ..::|.......||.|:|.
Zfish   231 GSNTLNGTASSSLSTANTSILPNIKVEKDSIIQLC-TPGVIKQENTGASYCQGGLHSTPI----- 289

  Fly    61 QLCSSTTSL--------SCDLHNVSLSNDGD---SLKGSGTSGGNG---GGGGGGTSG------- 104
            .:|..|||.        |.....|.|..|..   ::....||.|:|   ..|.|..||
Zfish   290 NICGVTTSSGQSFLFGNSSPTAVVGLQKDQKPDFNMYTPLTSSGDGWSRSQGFGNVSGMQQRASL 354

  Fly   105 ---------------GNATNASAGAGSGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRT 154
                           .:...:|||..:|:     .::||||.|.|||.||||.:|.:||.||||.
Zfish   355 CFSKNFSSSPYSRPEDSTATSSAGGKTGT-----HKICLVCSDEASGCHYGVLTCGSCKVFFKRA 414

  Fly   155 IQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKYRRNPVSNSYQ 219
            ::|...|.|...|:|.|:|.|||.|.||||:|||:.||..|      .|..:.|.|:   :....
Zfish   415 VEGQHNYLCAGRNDCIIDKIRRKNCPACRFRKCLMAGMNLE------ARKSKSKARQ---AGKVI 470

  Fly   220 TMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTP 284
            ..|.:.:.|...|.:.:.|            |..|.||:..|.::..:|             :.|
Zfish   471 QQQSIPERNLPPLPEARAL------------VPKPMPQLVPTMLSLLKA-------------IEP 510

  Fly   285 NGTCIFQNNNNNDPN---EILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEIL 346
            :  .::...::..|:   .:::.|:.:..::::|.:.|||.:|||.:|.|:|||.|||.||..|:
Zfish   511 D--TLYAGYDSTIPDTSVRLMTTLNRLGGRQVISAVKWAKALPGFRNLHLDDQMTLLQCSWLFIM 573

  Fly   347 TLQLTFRSLPF-NGK-LCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKAL 409
            :..|.:||... ||. ||||.|:.::|...|....::.....::|:....|:....|||..:|.|
Zfish   574 SFGLGWRSYQHCNGNMLCFAPDLVINEERMKLPYMSDQCEQMLKISNEFVRLQVSTEEYLCMKVL 638

  Fly   410 LLANC--DILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQ--QLLLLLPSL 461
            ||.|.  ...|..||.....|.:.:..|...:.....:|:.:.|:  ||..||.|:
Zfish   639 LLLNTVPKDGLKSQSVFDELRMSYIKELGKAIVKREENSSQNWQRFYQLTKLLDSM 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	43/95 (45%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	62/234 (26%)
nr3c1	NP_001018547.2	GCR	18..369	CDD:280340	33/143 (23%)
		NR_DBD_GR_PR	383..460	CDD:143546	41/87 (47%)
		NR_LBD_GR_Like	500..744	CDD:132745	57/210 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940