DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERR and PGR

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_000917.3	Gene:	PGR / 5241	HGNCID:	8910	Length:	933	Species:	Homo sapiens

Alignment Length:	609	Identity:	146/609 - (23%)
Similarity:	241/609 - (39%)	Gaps:	199/609 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LHIKQEVDTPSASCFSPSS------------------------KSTATQSGTNGLKSSPSVSPER 60
            |.||:|.:...||..||.|                        ::|.::.|...:.::|:.:...
Human   385 LKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVS 449

  Fly    61 QLCSSTTSLSCDLHNVSLSNDGDSLKGSGTSGGNG----------GGGG-----GGTSGGNATNA 110
            ...||.::|.|.|:           |..|.....|          |..|     .|....:|:.|
Human   450 SASSSGSTLECILY-----------KAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAA 503

  Fly   111 SAGAG------------------SGSVRDEL-----------------------------RRLCL 128
            :|||.                  :..:::.|                             :::||
Human   504 AAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICL 568

  Fly   129 VCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGML 193
            :|||.|||.||||.:|.:||.||||.::|...|.|...|:|.::|.|||.|.|||.:||...||
Human   569 ICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGM- 632

  Fly   194 KEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSY----------EPDA 248
                    |.|||:..:.|                     .|:::..|::.          |..|
Human   633 --------VLGGRKFKKFN---------------------KVRVVRALDAVALPQPVGVPNESQA 668

  Fly   249 LS----------VQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDP---NE 300
            ||          :|..||.::..             :.:|..|       |:..::|..|   :.
Human   669 LSQRFTFSPGQDIQLIPPLINLL-------------MSIEPDV-------IYAGHDNTKPDTSSS 713

  Fly   301 ILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLP-FNGK-LCF 363
            :|:.|:.:.:::|:||:.|:|.:|||.:|.::||:.|:|.||..::...|.:||.. .:|: |.|
Human   714 LLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYF 778

  Fly   364 ATDVWMDEHLAKECGYTEFYYHCV---QIAQRMERISPRREEYYLLKALLLANCDIL--LDDQSS 423
            |.|:.::|...||   :.||..|:   ||.|...::...:||:..:|.|||.|...|  |..|:.
Human   779 APDLILNEQRMKE---SSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 840

  Fly   424 LRAFRDTILNSLNDVVYLLRHSSAVSHQQQLLLLLPSLRQADDILRRFW----------RGIA-- 476
            ....|.:.:..|...:. ||....||..|:...|...|....|::::..          |.::
Human   841 FEEMRSSYIRELIKAIG-LRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVE 904

  Fly   477 ----RDEVIT--MKKLFLEMLEPL 494
                ..|||.  :.|:...|::||
Human   905 FPEMMSEVIAAQLPKILAGMVKPL 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	42/124 (34%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	73/303 (24%)
PGR	NP_000917.3	Modulating, Pro-Rich	1..566		29/191 (15%)
		Prog_receptor	1..564	CDD:280346	29/189 (15%)
		AF3, mediates transcriptional activation (in isoform B). /evidence=ECO:0000269\|PubMed:11546784	1..164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157
		LXXL motif 1. /evidence=ECO:0000305\|PubMed:11546784	55..59
		LXXL motif 2. /evidence=ECO:0000305\|PubMed:11546784	115..119
		Mediates transcriptional transrepression (in isoform A). /evidence=ECO:0000269\|PubMed:9407067	165..305
		Nuclear localization signal. /evidence=ECO:0000255	183..187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..351
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..452		3/36 (8%)
		AF1, mediates transcriptional activation. /evidence=ECO:0000269\|PubMed:1587864	456..546		15/100 (15%)
		NR_DBD_GR_PR	563..640	CDD:143546	40/85 (47%)
		NR_LBD_PR	686..933	CDD:132759	68/267 (25%)
		AF2, mediates transcriptional activation. /evidence=ECO:0000269\|PubMed:1587864	687..933		67/266 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940