Protein Alignment ERR and NR3C2

DIOPT Version :9

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_011530277.1
• Gene: NR3C2 / 4306
• HGNCID: 7979
• Length: 988
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 165/587 - (28%)
• Similarity: 245/587 - (41%)
• Gaps: 158/587 - (26%)

  Fly    13 MSDGVS-----ILHIKQEVDTP-SASC------------FSPSSKSTATQ---SGTNGLKSSPSV 56
            :|:||:     :.:||.|.|.. |:||            ||...|..:|:   |||: .|.:|:|
Human   384 ISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTS-FKGNPTV 447

  Fly    57 SPERQLCSSTTSLSCDLHNVSLS---------------------------NDGD-----SLKGSG 89
            :|...:..|..|...|....|||                           :||.     |:..|.
Human   448 NPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSA 512

  Fly    90 TSGGNGGG-------GGGGT-----------------------------SGGNAT---------- 108
            ..|.|.||       |..||                             |.|:.:
Human   513 IVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVL 577

  Fly   109 -----NASA----GAGSGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNI----E 160
                 |.|:    ...:||.|..  ::||||||.|||.||||.:|.:||.||||.::|..    .
Human   578 EYIPENVSSSTLRSVSTGSSRPS--KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGKCSWQHN 640

  Fly   161 YTCPANNECEINKRRRKACQACRFQKCLLMGM---LKEGVRLDRVRG----GRQKYRRNPVSNSY 218
            |.|...|:|.|:|.|||.|.|||.||||..||   .::..:|.:::|    ..|:.:..|.....
Human   641 YLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPP 705

  Fly   219 QTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTP-PPQVHTTSITNDEASSSSGSIKLESSVV 282
            |:.    :..||.:...|        ||   ||.|. .||:.|.|    .|.:.|..:.||:  :
Human   706 QSP----EEGTTYIAPAK--------EP---SVNTALVPQLSTIS----RALTPSPVMVLEN--I 749

  Fly   283 TPNGTCIFQNNNNNDPN---EILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAE 344
            .|.  .::...:::.|:   .:||.|:.:..|:::.|:.|||.:|||.:|||.||:.|:|.||..
Human   750 EPE--IVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMC 812

  Fly   345 ILTLQLTFRSLPFNGK--LCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLK 407
            :.:..|::||......  |.||.|:..:|....:....|......||:.:..|:....|||.::|
Human   813 LSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMK 877

  Fly   408 ALLLANCDILLDDQSSLRAF---RDTILNSLNDVVYLLRHSSAVSHQQ--QLLLLLPSLRQ-ADD 466
            .|||.: .|..|...|..||   |...:..|..:|....::|..|.|:  ||..||.|:.. ..|
Human   878 VLLLLS-TIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSD 941

  Fly   467 IL 468
            :|
Human   942 LL 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	44/106 (42%)
		NR_LBD	237..493	CDD:299703	72/244 (30%)
NR3C2	XP_011530277.1	NR_DBD_GR_PR	599..677	CDD:143546	40/79 (51%)
		NR_LBD_MR	741..988	CDD:132760	62/208 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940