DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERR and AR

DIOPT Version :9

Sequence 1:NP_648183.3 Gene:ERR / 38912 FlyBaseID:FBgn0035849 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_000035.2 Gene:AR / 367 HGNCID:644 Length:920 Species:Homo sapiens


Alignment Length:524 Identity:127/524 - (24%)
Similarity:213/524 - (40%) Gaps:168/524 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 SSTTSLSCDLHNVSLSNDGD---SLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSG-------- 117
            |.:.:.|...|.:..:.:|.   ...|.|..||.|||||||..||....|.|.|..|        
Human   426 SPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGL 490

  Fly   118 ---------------------------------------------------SVRDEL-------- 123
                                                               :.||.:        
Human   491 AGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFP 555

  Fly   124 -RRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKC 187
             ::.||:|||.|||.|||..:|.:||.||||..:|..:|.|.:.|:|.|:|.|||.|.:||.:||
Human   556 PQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKC 620

  Fly   188 LLMGMLKEGVRLDRVRGGRQKYRR-----NPVSNSYQTMQLLYQSNTTSL-CDVKILEVLNSYEP 246
            ...||.....:|.::  |..|.:.     :..|.:.:|.|.|..|:.... |....|.||.:.||
Human   621 YEAGMTLGARKLKKL--GNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEP 683

  Fly   247 DALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNE---ILSVLSDI 308
            ..                                        :...::||.|:.   :||.|:::
Human   684 GV----------------------------------------VCAGHDNNQPDSFAALLSSLNEL 708

  Fly   309 YDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLP-FNGK-LCFATDVWMDE 371
            .:::||.|:.|||.:|||.:|.::|||.::|.||..::...:.:||.. .|.: |.||.|:..:|
Human   709 GERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNE 773

  Fly   372 HLAKECGYTEFYYHCVQIAQRME-----RISPRREEYYLLKALLLANCDILLDDQSSLRAFRDTI 431
            :...:   :..|..||::....:     :|:|  :|:..:|||||.:. |.:|...:.:.|.:..
Human   774 YRMHK---SRMYSQCVRMRHLSQEFGWLQITP--QEFLCMKALLLFSI-IPVDGLKNQKFFDELR 832

  Fly   432 LNSLNDVVYLL----RHSSAVSHQQQLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLE 492
            :|.:.::..::    ::.::.|                   |||::         :.|| |:.::
Human   833 MNYIKELDRIIACKRKNPTSCS-------------------RRFYQ---------LTKL-LDSVQ 868

  Fly   493 PLAR 496
            |:||
Human   869 PIAR 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERRNP_648183.3 NR_DBD_ERR 121..217 CDD:143544 40/109 (37%)
NR_LBD 237..493 CDD:299703 57/269 (21%)
ARNP_000035.2 Interaction with ZNF318. /evidence=ECO:0000250|UniProtKB:P19091 1..587 40/160 (25%)
Modulating 1..559 23/132 (17%)
Androgen_recep 6..449 CDD:280349 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..167
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..228
Interaction with LPXN. /evidence=ECO:0000269|PubMed:18451096 552..919 104/398 (26%)
NR_DBD_AR 555..636 CDD:143547 36/82 (44%)
Interaction with HIPK3. /evidence=ECO:0000250|UniProtKB:P15207 572..662 33/91 (36%)
Interaction with CCAR1. /evidence=ECO:0000269|PubMed:23887938 592..919 85/358 (24%)
Interaction with KAT7. /evidence=ECO:0000269|PubMed:10930412 625..919 70/325 (22%)
NR_LBD_AR 673..918 CDD:132758 60/275 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145106
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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