DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERR and esr2a

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_851297.1	Gene:	esr2a / 317734	ZFINID:	ZDB-GENE-030116-2	Length:	553	Species:	Danio rerio

Alignment Length:	406	Identity:	138/406 - (33%)
Similarity:	201/406 - (49%)	Gaps:	89/406 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 CLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMG 191
            |.||.|.|||:||||.|||.|||||||:|||:.:|.|||.|:|.|:|.|||:|||||.:||..:|
Zfish   159 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVG 223

  Fly   192 MLKEGVRLDR----VRGGRQK---------YRRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLN- 242
            |:|.|:|.||    .||.:||         ....|.|...:::......|          ||:.
Zfish   224 MMKCGLRRDRSSYQQRGAQQKRLVRFSGRMRMTGPRSQEIKSIPRPLSGN----------EVVRI 278

  Fly   243 SYEPDAL---SVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSV 304
            |..|:.|   .::..||:::                 |...:..|     |...|      ::..
Zfish   279 SLSPEELISRIMEAEPPEIY-----------------LMKDMKKP-----FTEAN------VMMS 315

  Fly   305 LSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWM 369
            |:::.|||||.:|.|||:||||::|.|.||:.||:..|.|:|.|.|.:||:...|||.|:.|:.:
Zfish   316 LTNLADKELVHMISWAKKIPGFVELSLFDQVHLLECCWLEVLMLGLMWRSVNHPGKLIFSPDLCL 380

  Fly   370 --DEHLAKEC--GYTEFYYHCVQIAQRMERISPRREEYYLLKALLLANCDILL-------DDQSS 423
              ||   ..|  |..|.:...:....|...:..:||||..|||::|.|.::.|       |.||.
Zfish   381 SRDE---SSCVQGLVEIFDMLLAATSRFRELKLQREEYVCLKAMILLNSNMCLGSSEGGEDLQSR 442

  Fly   424 LRAFRDTILNSLNDVVYLLRHSSAVSHQQQ------LLLLLPSLRQADDILRRFWRGIARDEVIT 482
            .:..  .:|:|:.|.:......:.:|.||:      ||:||..:|...:      :|:.....:.
Zfish   443 SKLL--CLLDSVTDALVWAISKTGLSFQQRSTRLAHLLMLLSHIRHVSN------KGMDHLHCMK 499

  Fly   483 MKK------LFLEMLE 492
            |||      |.||||:
Zfish   500 MKKMVPLYDLLLEMLD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	55/102 (54%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	82/283 (29%)
esr2a	NP_851297.1	ERbeta_N	31..134	CDD:289279
		NR_DBD_ER	154..233	CDD:143545	47/73 (64%)
		NR_LBD_ER	280..517	CDD:132747	79/275 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940