DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and Esrra

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001008511.2	Gene:	Esrra / 293701	RGDID:	1583866	Length:	422	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	185/497 - (37%)
Similarity:	248/497 - (49%)	Gaps:	101/497 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GVSILHIKQEVDTPSASCFSPSSKSTATQSGTNGLKSSPSVSPERQLCSSTTSLSCDLHNVSLSN 80
            |:..|:||.|..:|.    ||        .|::..::.|.|:    |.|......| |.......
  Rat     7 GIEPLYIKAEPASPD----SP--------KGSSETETEPPVT----LASGPAPARC-LPGHKEEE 54

  Fly    81 DGDSLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELRRLCLVCGDVASGFHYGVASCE 145
            ||:            |.|.|....|....:|..          :||||||||||||:||||||||
  Rat    55 DGE------------GAGSGEQGSGKLVLSSLP----------KRLCLVCGDVASGYHYGVASCE 97

  Fly   146 ACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKYR 210
            ||||||||||||:|||:|||:|||||.||||||||||||.|||.:|||||||||||||||||||:
  Rat    98 ACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYK 162

  Fly   211 RNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSI 275
            |.|                               |.|.|....|.|............::...::
  Rat   163 RRP-------------------------------EVDPLPFPGPFPAGPLAVAGGPRKTAPVNAL 196

  Fly   276 KLESSVVTPNGTCIFQNNNNNDPN-EILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQ 339
            .....||.|.......:..:.|.: ..::.|.|::|:|:|..|.|||.||||..|.|:|||.:||
  Rat   197 VSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQ 261

  Fly   340 VSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYY 404
            ..|.|:|.|.:..||||...:|.||.|:.:||..|:..|..:.....:|:.:|::.:...||||.
  Rat   262 SVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYV 326

  Fly   405 LLKALLLANCD-ILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQ---------------Q 453
            |||||.|||.| :.::|..::...|:.:            |.:.:.::.               :
  Rat   327 LLKALALANSDSVHIEDAEAVEQLREAL------------HEALLEYEAGRAGPGGGAERRRAGR 379

  Fly   454 LLLLLPSLRQ-ADDILRRFWRGIARDEVITMKKLFLEMLEPL 494
            |||.||.||| |..:|..|: |:..:..:.|.||||||||.:
  Rat   380 LLLTLPLLRQTAGKVLAHFY-GVKLEGKVPMHKLFLEMLEAM 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/95 (83%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	83/273 (30%)
Esrra	NP_001008511.2	Repressor domain. /evidence=ECO:0000250	1..76		22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66		20/87 (23%)
		NR_DBD_ERR	73..168	CDD:143544	81/135 (60%)
		NR_LBD_ERR	196..419	CDD:132744	78/235 (33%)
		AF-2 domain. /evidence=ECO:0000250	402..422		9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338812
Domainoid	1	1.000	138	1.000	Domainoid score	I4712
eggNOG	1	0.900	-	-		E33208_3BAW9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297679at33208
OrthoFinder	1	1.000	-	-		FOG0001624
OrthoInspector	1	1.000	-	-		otm45415
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1027
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860