DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERR and Esrrg

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_036065.1	Gene:	Esrrg / 26381	MGIID:	1347056	Length:	458	Species:	Mus musculus

Alignment Length:	505	Identity:	192/505 - (38%)
Similarity:	258/505 - (51%)	Gaps:	95/505 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LHIKQEVDTPSASCFSPSSKSTATQSGTNGLKSSPSVSPERQLCSSTTSLSCDLHNVSLSNDGDS 84
            ||.::|:     .|...:.......|.::.:|:.|         ||..||:..:::.|.....|:
Mouse    14 LHYEEEL-----LCRMSNKDRHIDSSCSSFIKTEP---------SSPASLTDSVNHHSPGGSSDA 64

  Fly    85 LKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVR---DEL--------------------RRL 126
             .||.:|..| |...|..|.....:|....|||.||   |:.                    :||
Mouse    65 -SGSYSSTMN-GHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRL 127

  Fly   127 CLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMG 191
            ||||||:|||:||||||||||||||||||||||||:|||.|||||.|||||:||||||.|||.:|
Mouse   128 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 192

  Fly   192 MLKEGVRLDRVRGGRQKY-RRNPVSNS-YQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTP 254
            |||||||||||||||||| ||....|| |...||:..:....   .||:..|...||:.:... |
Mouse   193 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPY---NKIVSHLLVAEPEKIYAM-P 253

  Fly   255 PPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGW 319
            .|.|..:.|                                    :.|:.|.|:.|:|||.:|||
Mouse   254 DPTVPDSDI------------------------------------KALTTLCDLADRELVVIIGW 282

  Fly   320 AKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYY 384
            ||.||||..|.|.|||.|||.:|.|||.|.:.:|||.|..:|.:|.|..|||..:|..|..:...
Mouse   283 AKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNN 347

  Fly   385 HCVQIAQRMERISPRREEYYLLKALLLANCDIL-LDDQSSLRAFRDTILNSLNDVVYLLRHSSAV 448
            ..:|:.::.:.:...:||:..|||:.|||.|.: ::|..:::..:|.:..:|.|.       .|.
Mouse   348 AILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDY-------EAG 405

  Fly   449 SHQQ------QLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLE 492
            .|.:      ::|:.||.|||......:.:..|..:..:.|.||||||||
Mouse   406 QHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/116 (68%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	81/263 (31%)
Esrrg	NP_036065.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..85		14/53 (26%)
		NR_DBD_ERR	122..218	CDD:143544	78/95 (82%)
		NR_LBD_ERR	237..456	CDD:132744	81/263 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835216
Domainoid	1	1.000	138	1.000	Domainoid score	I4814
eggNOG	1	0.900	-	-		E33208_3BAW9
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55581
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2873
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297679at33208
OrthoFinder	1	1.000	-	-		FOG0001624
OrthoInspector	1	1.000	-	-		otm43343
orthoMCL	1	0.900	-	-		OOG6_106347
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5621
SonicParanoid	1	1.000	-	-		X1027
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790