DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERR and Nr3c2

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_038953451.1	Gene:	Nr3c2 / 25672	RGDID:	3094	Length:	985	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	162/581 - (27%)
Similarity:	243/581 - (41%)	Gaps:	150/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MSDGVS-----ILHIKQEVDTP-SASC------FSPSS------KSTATQSGTNG--LKSSPSVS 57
            :|:||:     :.:||.|.|.. |:||      .||||      |..:::...:|  .|.:|:|:
  Rat   385 ISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVN 449

  Fly    58 PERQLCSSTTSLSCDLHNVSLS---------------------------NDGD-----SLKGSGT 90
            |...:..|..|...|....|||                           :||.     |:..|..
  Rat   450 PFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEGSAFPVGIKQEPDDGSYYPEASIPSSAI 514

  Fly    91 SGGNGGG-------GGGGT------------------------------SGGNATNASAG----- 113
            .|.|.||       |..||                              .|..::..|.|
  Rat   515 VGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLE 579

  Fly   114 -------------AGSGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNI----EY 161
                         ..:||.|..  ::||||||.|||.||||.:|.:||.||||.::|..    .|
  Rat   580 YIPENVSSSTLRSVSTGSSRPS--KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGKCSWQHNY 642

  Fly   162 TCPANNECEINKRRRKACQACRFQKCLLMGM---LKEGVRLDRVRGGRQKYRRNPVSNSYQTMQL 223
            .|...|:|.|:|.|||.|.|||.||||..||   .::..:|.:::|..::..:.|.....|:.
  Rat   643 LCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSP-- 705

  Fly   224 LYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTC 288
              :..||.:...|        ||...|...|    ..||||:  |.:.|.::.||:  :.|.  .
  Rat   706 --EEGTTYIAPTK--------EPSVNSALVP----QLTSITH--ALTPSPAMILEN--IEPE--T 750

  Fly   289 IFQNNNNNDPN---EILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQL 350
            ::...:|:.|:   .:||.|:.:..|:::.|:.|||.:|||.:|||.||:.|:|.||..:.:..|
  Rat   751 VYAGYDNSKPDTAESLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFAL 815

  Fly   351 TFRSLPFNGK--LCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKALLLAN 413
            ::||......  |.||.|:..:|....:....|......||:.:..|:....|||.::|.|||.:
  Rat   816 SWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLS 880

  Fly   414 CDILLDDQSSLRAF---RDTILNSLNDVVYLLRHSSAVSHQQ--QLLLLLPSLRQ-ADDIL 468
             .:..|...|..||   |...:..|..:|....:||..|.|:  ||..||.|:.. ..|:|
  Rat   881 -TVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	43/102 (42%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	72/243 (30%)
Nr3c2	XP_038953451.1	NR_DBD_GR_PR	600..678	CDD:143546	40/79 (51%)
Nr3c2	XP_038953451.1	NR_LBD_MR	738..985	CDD:132760	63/208 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940