DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERR and Pgr

DIOPT Version :9

Sequence 1:NP_648183.3 Gene:ERR / 38912 FlyBaseID:FBgn0035849 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_074038.2 Gene:Pgr / 25154 RGDID:3317 Length:926 Species:Rattus norvegicus


Alignment Length:618 Identity:153/618 - (24%)
Similarity:241/618 - (38%) Gaps:194/618 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 QGTNMSDGVSI--------LHIKQEVDTPSASCFSP-----SSKSTAT----------------- 43
            :|....||..:        |.||:|.:...|:..||     :..|.||                 
  Rat   366 EGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPPAPPRAPPSR 430

  Fly    44 --QSGTNGLKSSPSVSPERQLCSSTTSLSCDLHNV---------------------SLSNDGDSL 85
              ::...|...|.:|||   :.||.::|.|.|:..                     |.....|||
  Rat   431 PGEAAVAGGPGSAAVSP---VSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSL 492

  Fly    86 KGSGTS----------GGNGGGGGGGTSGGNATNASAGAGSGSVRDEL----------------- 123
            ..:.||          |.||             ....|..:..::|.|                 
  Rat   493 PAAPTSSAAPAIYPPLGLNG-------------LPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEA 544

  Fly   124 ------------RRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRR 176
                        :::||:|||.|||.||||.:|.:||.||||.::|...|.|...|:|.::|.||
  Rat   545 SQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRR 609

  Fly   177 KACQACRFQKCLLMGMLKEG--------VRLDRVRGGRQKYRRNPVSNSYQTM--QLLYQSNTTS 231
            |.|.|||.:||...||:..|        ||:.|...|....:...:.|..||:  ::.:..|...
  Rat   610 KNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDGVALPQSVGLPNESQTLGQRITFSPNQEI 674

  Fly   232 LCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNN 296
            .....::.:|.|.|||.                                        ::..::|.
  Rat   675 QLVPPLINLLMSIEPDV----------------------------------------VYAGHDNT 699

  Fly   297 DP---NEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLP-F 357
            .|   :.:|:.|:.:.:::|:||:.|:|.:|||.:|.::||:.|:|.||..::...|.:||.. .
  Rat   700 KPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHV 764

  Fly   358 NGK-LCFATDVWMDEHLAKECGYTEFYYHCV---QIAQRMERISPRREEYYLLKALLLANCDIL- 417
            :|: |.||.|:.::|...||   ..||..|:   ||.|...::....||:..:|.|||.|...| 
  Rat   765 SGQMLYFAPDLILNEQRMKE---LSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLE 826

  Fly   418 -LDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQ--QLLLLLPSLRQADDILRRFW------- 472
             |..||.....|.:.:..|...:.|.:.....|.|:  ||..||.||.   |::::..       
  Rat   827 GLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDSLH---DLVKQLHLYCLNTF 888

  Fly   473 ---RGIA------RDEVIT--MKKLFLEMLEPL 494
               |.:|      ..|||.  :.|:...|::||
  Rat   889 IQSRALAVEFPEMMSEVIAAQLPKILAGMVKPL 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERRNP_648183.3 NR_DBD_ERR 121..217 CDD:143544 43/132 (33%)
NR_LBD 237..493 CDD:299703 71/285 (25%)
PgrNP_074038.2 Prog_receptor 1..557 CDD:396643 35/206 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49
LXXL motif 1. /evidence=ECO:0000250|UniProtKB:P06401 56..60
LXXL motif 2. /evidence=ECO:0000250|UniProtKB:P06401 116..120
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..240
Mediates transcriptional transrepression (in isoform A). /evidence=ECO:0000250|UniProtKB:P06401 166..305
Nuclear localization signal. /evidence=ECO:0000255 185..189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 334..372 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..436 1/22 (5%)
AF1, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401 453..539 15/98 (15%)
NR_DBD_GR_PR 556..633 CDD:143546 37/76 (49%)
NR_LBD_PR 679..926 CDD:132759 73/289 (25%)
AF2, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401 680..926 73/288 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48092
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

Return to query results.
Submit another query.