DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and Nr3c1

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_017456328.1	Gene:	Nr3c1 / 24413	RGDID:	2741	Length:	795	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	151/522 - (28%)
Similarity:	218/522 - (41%)	Gaps:	113/522 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IKQEVDTPSASCFSPSSKSTATQSGTN--GLKSSPSVSPERQLCSSTTSLSCDLHNVSLSNDGDS 84
            ||||...| ..|       .|:.||||  |.|.| ::|......|.......|::..|||...|.
  Rat   311 IKQEKLGP-VYC-------QASFSGTNIIGNKMS-AISVHGVSTSGGQMYHYDMNTASLSQQQDQ 366

  Fly    85 -------------------LKGSG----TSGG-----------NGGGGGGGTSGGNATNASAGAG 115
                               .:|||    ||.|           ||....|.....::..:|:.|.
  Rat   367 KPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRPDVSSPPSSSSAA 431

  Fly   116 SGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQG-NIEYTCPANNECEINKRRRKAC 179
            :|..    .:|||||.|.|||.||||.:|.:||.||||.::| ...|.|...|:|.|:|.|||.|
  Rat   432 TGPP----PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNC 492

  Fly   180 QACRFQKCLLMGMLKEGVRLDR--------VRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVK 236
            .|||::|||..||..|..:..:        ..|..|....||  |.......|.|...|.   |.
  Rat   493 PACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENP--NKTIVPAALPQLTPTL---VS 552

  Fly   237 ILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEI 301
            :|||:   ||:.|..                        ..:|||  |:...           .|
  Rat   553 LLEVI---EPEVLYA------------------------GYDSSV--PDSAW-----------RI 577

  Fly   302 LSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSL--PFNGKLCFA 364
            ::.|:.:..:::::.:.|||.||||.:|.|:|||.|||.||..::...|.:||.  .....||||
  Rat   578 MTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFA 642

  Fly   365 TDVWMDE-HLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKALLLANC--DILLDDQSSLRA 426
            .|:.::| .::..|.|.: ..|.:.::..::|:....|||..:|.|||.:.  ...|..|.....
  Rat   643 PDLIINEQRMSLPCMYDQ-CKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDE 706

  Fly   427 FRDTILNSLNDVVYLLRHSSAVSHQQ--QLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLE 489
            .|.|.:..|...:.....:|:.:.|:  ||..||.|:.:..:.|..:......|:  ||...|.|
  Rat   707 IRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDK--TMSIEFPE 769

  Fly   490 ML 491
            ||
  Rat   770 ML 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	44/104 (42%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	69/262 (26%)
Nr3c1	XP_017456328.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010