DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERR and Ar

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_036634.2	Gene:	Ar / 24208	RGDID:	2147	Length:	902	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	143/641 - (22%)
Similarity:	236/641 - (36%)	Gaps:	230/641 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GEGQGTNMSDGVSILH--IKQEVDTPSASCFSPSSKSTATQSGTNGLKSSPSVSPERQLCSSTTS 68
            |.|:||..:...|...  ..:.::..|..|   |..|.|..|||..:.||.|:.....:..:...
  Rat   294 GPGKGTEETAEYSSFKGGYAKGLEGESLGC---SGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAY 355

  Fly    69 LSCDLHN--------------------VSLSND----------------GD--SLKGSGTSGGN- 94
            .:.|.:|                    :.|.|.                ||  ||.|...:|.:
  Rat   356 QNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGGSVAGPST 420

  Fly    95 -----------------------GGGGGGGTSGGNATNASAGAG--------------------- 115
                                   |.|||||:|..:.....|..|
  Rat   421 GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFSASEVW 485

  Fly   116 ----------------------------SG--------SVRDEL---------RRLCLVCGDVAS 135
                                        ||        |.||.:         ::.||:|||.||
  Rat   486 YPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEAS 550

  Fly   136 GFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGM------LK 194
            |.|||..:|.:||.||||..:|..:|.|.:.|:|.|:|.|||.|.:||.:||...||      ||
  Rat   551 GCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLK 615

  Fly   195 EGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVH 259
            :...|.....|......:|..:..|.|.:.:.....  |....|.||.:.||..
  Rat   616 KLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYE--CQPIFLNVLEAIEPGV----------- 667

  Fly   260 TTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNE---ILSVLSDIYDKELVSVIGWAK 321
                                         :...::||.|:.   :||.|:::.:::||.|:.|||
  Rat   668 -----------------------------VCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK 703

  Fly   322 QIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLP-FNGK-LCFATDVWMDEHLAKECGYTEFYY 384
            .:|||.:|.::|||.::|.||..::...:.:||.. .|.: |.||.|:..:|:...:   :..|.
  Rat   704 ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHK---SRMYS 765

  Fly   385 HCVQIAQRME-----RISPRREEYYLLKALLLANCDILLDDQSSLRAFRDTILNSLNDVVYLL-- 442
            .||::....:     :|:|  :|:..:|||||.:. |.:|...:.:.|.:..:|.:.::..::
  Rat   766 QCVRMRHLSQEFGWLQITP--QEFLCMKALLLFSI-IPVDGLKNQKFFDELRMNYIKELDRIIAC 827

  Fly   443 --RHSSAVSHQQQLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLEPLAR 496
              ::.::.|                   |||::         :.|| |:.::|:||
  Rat   828 KRKNPTSCS-------------------RRFYQ---------LTKL-LDSVQPIAR 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	41/110 (37%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	57/269 (21%)
Ar	NP_036634.2	Interaction with ZNF318. /evidence=ECO:0000250\|UniProtKB:P19091	1..569		57/277 (21%)
		Modulating	1..540		40/248 (16%)
		Androgen_recep	6..443	CDD:396645	26/151 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..224
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..465		8/25 (32%)
		Interaction with LPXN. /evidence=ECO:0000250\|UniProtKB:P10275	534..901		103/398 (26%)
		NR_DBD_AR	537..618	CDD:143547	37/80 (46%)
		Interaction with HIPK3. /evidence=ECO:0000269\|PubMed:9725910	554..644		33/89 (37%)
		Interaction with CCAR1. /evidence=ECO:0000250\|UniProtKB:P10275	574..901		84/358 (23%)
		Interaction with KAT7. /evidence=ECO:0000250\|UniProtKB:P10275	607..901		69/325 (21%)
		NR_LBD_AR	655..900	CDD:132758	60/275 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940