DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERR and ESRRG

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_011507567.1	Gene:	ESRRG / 2104	HGNCID:	3474	Length:	477	Species:	Homo sapiens

Alignment Length:	504	Identity:	193/504 - (38%)
Similarity:	254/504 - (50%)	Gaps:	109/504 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GTNGLKSSPSVSPERQLC---------------------SSTTSLSCDLHNVSLSNDGDSLKGSG 89
            |.:||::.      |.||                     ||..||:..:::.|.....|: .||.
Human    23 GVSGLEAG------RLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDA-SGSY 80

  Fly    90 TSGGNGGGGGGGTSGGNATNASAGAGSGSVR---DEL--------------------RRLCLVCG 131
            :|..| |...|..|.....:|....|||.||   |:.                    :|||||||
Human    81 SSTMN-GHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCG 144

  Fly   132 DVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEG 196
            |:|||:||||||||||||||||||||||||:|||.|||||.|||||:||||||.|||.:||||||
Human   145 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEG 209

  Fly   197 VRLDRVRGGRQKY-RRNPVSNS-YQTMQLLYQSNTTSL----CDVKILEVLNSYEPDALSVQTPP 255
            ||||||||||||| ||....|| |...||:..:....|    .|.||:..|...||:.:... |.
Human   210 VRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEKIYAM-PD 273

  Fly   256 PQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWA 320
            |.|..:.|                                    :.|:.|.|:.|:|||.:||||
Human   274 PTVPDSDI------------------------------------KALTTLCDLADRELVVIIGWA 302

  Fly   321 KQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYH 385
            |.||||..|.|.|||.|||.:|.|||.|.:.:|||.|..:|.:|.|..|||..:|..|..:....
Human   303 KHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNA 367

  Fly   386 CVQIAQRMERISPRREEYYLLKALLLANCDIL-LDDQSSLRAFRDTILNSLNDVVYLLRHSSAVS 449
            .:|:.::.:.:...:||:..|||:.|||.|.: ::|..:::..:|.:..:|.|.       .|..
Human   368 ILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDY-------EAGQ 425

  Fly   450 HQQ------QLLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLE 492
            |.:      ::|:.||.|||......:.:..|..:..:.|.||||||||
Human   426 HMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/116 (68%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	81/263 (31%)
ESRRG	XP_011507567.1	NR_DBD_ERR	134..230	CDD:143544	78/95 (82%)
ESRRG	XP_011507567.1	NR_LBD_ERR	256..475	CDD:132744	81/263 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145109
Domainoid	1	1.000	138	1.000	Domainoid score	I4842
eggNOG	1	0.900	-	-		E33208_3BAW9
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55581
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2723
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297679at33208
OrthoFinder	1	1.000	-	-		FOG0001624
OrthoInspector	1	1.000	-	-		otm41287
orthoMCL	1	0.900	-	-		OOG6_106347
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5621
SonicParanoid	1	1.000	-	-		X1027
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790