DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and ESRRB

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_011534849.1	Gene:	ESRRB / 2103	HGNCID:	3473	Length:	573	Species:	Homo sapiens

Alignment Length:	471	Identity:	197/471 - (41%)
Similarity:	251/471 - (53%)	Gaps:	78/471 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SPERQLCSSTTSLSCDLHNVSLSNDGDSLKGSGTSGGNGGGGGGGTSGGNATN--------ASAG 113
            |.:|.|.||..|. ......|.|:..|:|.....||.:...||.|.:.|...|        |.||
Human    24 SDDRHLGSSCGSF-IKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAG 87

  Fly   114 AG------------SGSVRDEL-----------RRLCLVCGDVASGFHYGVASCEACKAFFKRTI 155
            .|            ||.:.|..           :||||||||:|||:||||||||||||||||||
Human    88 LGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTI 152

  Fly   156 QGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQKYRR--NPVSNSY 218
            ||||||:|||.|||||.|||||:||||||.|||.:|||||||||||||||||||:|  :..|:.|
Human   153 QGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPY 217

  Fly   219 QTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGSIKLESSVVT 283
            .::|:   |........||:..|...|||.|....||             ....|.||
Human   218 LSLQI---SPPAKKPLTKIVSYLLVAEPDKLYAMPPP-------------GMPEGDIK------- 259

  Fly   284 PNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTL 348
                             .|:.|.|:.|:|||.:|||||.||||..|.|.|||.|||.:|.|||.|
Human   260 -----------------ALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILIL 307

  Fly   349 QLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEYYLLKALLLAN 413
            .:.:||||::.||.:|.|..|||..::..|..|.|...:|:.:|.:::...:||:..||||.|||
Human   308 GIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALAN 372

  Fly   414 CD-ILLDDQSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQQLLLLLPSLRQ-ADDILRRFWRGIA 476
            .| :.::|..:::..:|.:..:|.|.....||... ....:|||.||.||| |...::.|: .:.
Human   373 SDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEP-WRTGKLLLTLPLLRQTAAKAVQHFY-SVK 435

  Fly   477 RDEVITMKKLFLEMLE 492
            ....:.|.||||||||
Human   436 LQGKVPMHKLFLEMLE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	79/108 (73%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	91/258 (35%)
ESRRB	XP_011534849.1	NR_DBD_ERR	119..214	CDD:143544	77/94 (82%)
		NR_LBD_ERR	233..452	CDD:132744	91/258 (35%)
		MPLKIP	455..>524	CDD:292140
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145110
Domainoid	1	1.000	138	1.000	Domainoid score	I4842
eggNOG	1	0.900	-	-		E33208_3BAW9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2723
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D297679at33208
OrthoFinder	1	1.000	-	-		FOG0001624
OrthoInspector	1	1.000	-	-		otm41287
orthoMCL	1	0.900	-	-		OOG6_106347
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5621
SonicParanoid	1	1.000	-	-		X1027
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790