DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and ESR2

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001428.1	Gene:	ESR2 / 2100	HGNCID:	3468	Length:	530	Species:	Homo sapiens

Alignment Length:	512	Identity:	157/512 - (30%)
Similarity:	240/512 - (46%)	Gaps:	93/512 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HIKQEVDTPSASCFSPS-------SKSTATQSGTNGLKSSPSV--------SP---ERQL----C 63
            ::....:.|:.:.:||:       |..|..:.|.....:||:|        ||   .|||    .
Human    36 YVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYA 100

  Fly    64 SSTTSLSCDLHNV--SLSNDGDSLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELRRL 126
            ....|..|:..::  :|..:.::||..             .||...  ||...|.||.||  ...
Human   101 EPQKSPWCEARSLEHTLPVNRETLKRK-------------VSGNRC--ASPVTGPGSKRD--AHF 148

  Fly   127 CLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMG 191
            |.||.|.|||:||||.|||.|||||||:|||:.:|.|||.|:|.|:|.|||:|||||.:||..:|
Human   149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVG 213

  Fly   192 MLKEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILE-VLNSYEPDAL---SVQ 252
            |:|.|.|  |.|.|.:..||.  .::.:.:....::..:.....::.| :|::..|:.|   .::
Human   214 MVKCGSR--RERCGYRLVRRQ--RSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLE 274

  Fly   253 TPPPQVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVI 317
            ..||.|   .|:...|..:..|:.:.                          |:.:.|||||.:|
Human   275 AEPPHV---LISRPSAPFTEASMMMS--------------------------LTKLADKELVHMI 310

  Fly   318 GWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKEC--GYT 380
            .|||:||||::|.|.||::||:..|.|:|.:.|.:||:...|||.||.|:.:|....| |  |..
Human   311 SWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGK-CVEGIL 374

  Fly   381 EFYYHCVQIAQRMERISPRREEYYLLKALLLANCDI-----LLDDQSSLRAFRDTILNSLNDVVY 440
            |.:...:....|...:..:.:||..:||::|.|..:     ...|..|.|.... :||::.|.:.
Human   375 EIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAH-LLNAVTDALV 438

  Fly   441 LLRHSSAVSHQQQ------LLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEML 491
            .:...|.:|.|||      ||:||..:|.|.:........:....|:.:..|.||||
Human   439 WVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEML 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	53/95 (56%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	77/272 (28%)
ESR2	NP_001428.1	Modulating	1..148		28/128 (22%)
		ERbeta_N	16..122	CDD:289279	17/85 (20%)
		NR_DBD_ER	144..225	CDD:143545	51/84 (61%)
		NR_LBD_ER	263..498	CDD:132747	75/264 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940