DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERR and Pgr

DIOPT Version :9

Sequence 1:NP_648183.3 Gene:ERR / 38912 FlyBaseID:FBgn0035849 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_032855.2 Gene:Pgr / 18667 MGIID:97567 Length:926 Species:Mus musculus


Alignment Length:593 Identity:151/593 - (25%)
Similarity:241/593 - (40%) Gaps:174/593 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LHIKQEVDTPSASCFSP-------SSKST--------------ATQSGTNGLKSSPSVSPERQLC 63
            |.||:|.:...|:..||       :|.||              :::.|...:...||.:......
Mouse   385 LKIKEEEEGADAAVRSPRPYLSAGASSSTFPDFPLAPAPQRAPSSRPGEAAVAGGPSSAAVSPAS 449

  Fly    64 SSTTSLSCDLHNVSLSNDGDSLKGSGTSGGNGG---------GGGG------GTSGGNATNAS-- 111
            ||.::|.|.|:           |..|.....|.         ..|.      ......||.|:  
Mouse   450 SSGSALECILY-----------KAEGAPPTQGSFAPLPCKPPAAGSCLLPRDSLPAAPATAAAPA 503

  Fly   112 ------------AGAGSGSVRDEL-----------------------------RRLCLVCGDVAS 135
                        .|..:..::|.|                             :::||:|||.||
Mouse   504 IYQPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEAS 568

  Fly   136 GFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLD 200
            |.||||.:|.:||.||||.::|...|.|...|:|.::|.|||.|.|||.:||...||        
Mouse   569 GCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGM-------- 625

  Fly   201 RVRGGRQKYRRNPVSNSYQTMQ-----LLYQS----NTTSLCDVKILEVLNSYEPDALSVQTPPP 256
             |.||| |:::   .|..:.|:     .|.||    |.:.....:|     ::.|:. .:|..||
Mouse   626 -VLGGR-KFKK---FNKVRVMRTLDGVALPQSVGLPNESQALGQRI-----TFSPNQ-EIQLVPP 679

  Fly   257 QVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDP---NEILSVLSDIYDKELVSVIG 318
            .::..             :.:|..||       :..::|..|   :.:|:.|:.:.:::|:||:.
Mouse   680 LINLL-------------MSIEPDVV-------YAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK 724

  Fly   319 WAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLP-FNGK-LCFATDVWMDEHLAKECGYTE 381
            |:|.:|||.:|.::||:.|:|.||..::...|.:||.. .:|: |.||.|:.::|...||   ..
Mouse   725 WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKE---LS 786

  Fly   382 FYYHCV---QIAQRMERISPRREEYYLLKALLLANCDIL--LDDQSSLRAFRDTILNSLNDVVYL 441
            ||..|:   ||.|...::....||:..:|.|||.|...|  |..||.....|.:.:..|...:.|
Mouse   787 FYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGL 851

  Fly   442 LRHSSAVSHQQ--QLLLLLPSLRQADDILRRFW----------RGIA------RDEVIT--MKKL 486
            .:.....|.|:  ||..||.||.   |::::..          |.:|      ..|||.  :.|:
Mouse   852 RQKGVVPSSQRFYQLTKLLDSLH---DLVKQLHLYCLNTFIQSRTLAVEFPEMMSEVIAAQLPKI 913

  Fly   487 FLEMLEPL 494
            ...|::||
Mouse   914 LAGMVKPL 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERRNP_648183.3 NR_DBD_ERR 121..217 CDD:143544 43/124 (35%)
NR_LBD 237..493 CDD:299703 74/285 (26%)
PgrNP_032855.2 Modulating, Pro-Rich 1..559 28/184 (15%)
Prog_receptor 1..557 CDD:308007 28/182 (15%)
AF3, mediates transcriptional activation (in isoform B). /evidence=ECO:0000250|UniProtKB:P06401 1..165
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48
LXXL motif 1. /evidence=ECO:0000250|UniProtKB:P06401 56..60
LXXL motif 1. /evidence=ECO:0000250|UniProtKB:P06401 116..120
Mediates transcriptional transrepression (in isoform A). /evidence=ECO:0000250|UniProtKB:P06401 166..305
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..256
Nuclear localization signal. /evidence=ECO:0000255 184..188
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..364
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..447 9/55 (16%)
AF1, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401 453..539 13/96 (14%)
NR_DBD_GR_PR 556..633 CDD:143546 41/86 (48%)
AF2, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401 673..926 74/275 (27%)
NR_LBD_PR 679..926 CDD:132759 72/269 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835209
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.940

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