Protein Alignment ERR and Pgr

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_032855.2
• Gene: Pgr / 18667
• MGIID: 97567
• Length: 926
• Species: Mus musculus
• Alignment Length: 593
• Identity: 151/593 - (25%)
• Similarity: 241/593 - (40%)
• Gaps: 174/593 - (29%)

  Fly    20 LHIKQEVDTPSASCFSP-------SSKST--------------ATQSGTNGLKSSPSVSPERQLC 63
            |.||:|.:...|:..||       :|.||              :::.|...:...||.:......
Mouse   385 LKIKEEEEGADAAVRSPRPYLSAGASSSTFPDFPLAPAPQRAPSSRPGEAAVAGGPSSAAVSPAS 449

  Fly    64 SSTTSLSCDLHNVSLSNDGDSLKGSGTSGGNGG---------GGGG------GTSGGNATNAS-- 111
            ||.::|.|.|:           |..|.....|.         ..|.      ......||.|:
Mouse   450 SSGSALECILY-----------KAEGAPPTQGSFAPLPCKPPAAGSCLLPRDSLPAAPATAAAPA 503

  Fly   112 ------------AGAGSGSVRDEL-----------------------------RRLCLVCGDVAS 135
                        .|..:..::|.|                             :::||:|||.||
Mouse   504 IYQPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEAS 568

  Fly   136 GFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLD 200
            |.||||.:|.:||.||||.::|...|.|...|:|.::|.|||.|.|||.:||...||
Mouse   569 GCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGM-------- 625

  Fly   201 RVRGGRQKYRRNPVSNSYQTMQ-----LLYQS----NTTSLCDVKILEVLNSYEPDALSVQTPPP 256
             |.||| |:::   .|..:.|:     .|.||    |.:.....:|     ::.|:. .:|..||
Mouse   626 -VLGGR-KFKK---FNKVRVMRTLDGVALPQSVGLPNESQALGQRI-----TFSPNQ-EIQLVPP 679

  Fly   257 QVHTTSITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDP---NEILSVLSDIYDKELVSVIG 318
            .::..             :.:|..||       :..::|..|   :.:|:.|:.:.:::|:||:.
Mouse   680 LINLL-------------MSIEPDVV-------YAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK 724

  Fly   319 WAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLP-FNGK-LCFATDVWMDEHLAKECGYTE 381
            |:|.:|||.:|.::||:.|:|.||..::...|.:||.. .:|: |.||.|:.::|...||   ..
Mouse   725 WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKE---LS 786

  Fly   382 FYYHCV---QIAQRMERISPRREEYYLLKALLLANCDIL--LDDQSSLRAFRDTILNSLNDVVYL 441
            ||..|:   ||.|...::....||:..:|.|||.|...|  |..||.....|.:.:..|...:.|
Mouse   787 FYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGL 851

  Fly   442 LRHSSAVSHQQ--QLLLLLPSLRQADDILRRFW----------RGIA------RDEVIT--MKKL 486
            .:.....|.|:  ||..||.||.   |::::..          |.:|      ..|||.  :.|:
Mouse   852 RQKGVVPSSQRFYQLTKLLDSLH---DLVKQLHLYCLNTFIQSRTLAVEFPEMMSEVIAAQLPKI 913

  Fly   487 FLEMLEPL 494
            ...|::||
Mouse   914 LAGMVKPL 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	43/124 (35%)
		NR_LBD	237..493	CDD:472173	74/285 (26%)
Pgr	NP_032855.2	Modulating, Pro-Rich	1..559		28/184 (15%)
		Prog_receptor	1..557	CDD:460470	28/182 (15%)
		AF3, mediates transcriptional activation (in isoform B). /evidence=ECO:0000250|UniProtKB:P06401	1..165
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		LXXL motif 1. /evidence=ECO:0000250|UniProtKB:P06401	56..60
		LXXL motif 1. /evidence=ECO:0000250|UniProtKB:P06401	116..120
		Mediates transcriptional transrepression (in isoform A). /evidence=ECO:0000250|UniProtKB:P06401	166..305
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..256
		Nuclear localization signal. /evidence=ECO:0000255	184..188
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..364
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..447		9/55 (16%)
		AF1, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401	453..539		13/96 (14%)
		NR_DBD_GR_PR	556..633	CDD:143546	41/86 (48%)
		AF2, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401	673..926		74/275 (27%)
		NR_LBD_PR	679..926	CDD:132759	72/269 (27%)