DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ERR and nhr-102

DIOPT Version :9

Sequence 1:	NP_648183.3	Gene:	ERR / 38912	FlyBaseID:	FBgn0035849	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_506967.1	Gene:	nhr-102 / 180062	WormBaseID:	WBGene00003692	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	401	Identity:	85/401 - (21%)
Similarity:	138/401 - (34%)	Gaps:	136/401 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 TSGGNATNASAGAGSGSVRDELRRLCLVCGDVASGFHYGVASCEACKAFFKRTI--QGNIEYTCP 164
            ||...:|:.::.|           :|.|||..|.|.|:||.:|.||.|||:||:  :...:|.|.
Worm    10 TSSETSTSPASTA-----------ICKVCGLCAHGLHFGVLACRACAAFFRRTVVMERQKKYKCR 63

  Fly   165 ANNE-CEINKRRRKACQACRFQKCLLMGMLKEGVRLDR--VRGGRQKYRRNPVSNSYQTMQLLYQ 226
            ...: |.::...|..|:.|||.||:.:||..|.|:.:|  :...|::....|:..:.....:.|.
Worm    64 GGEDNCAVSSTDRYQCRLCRFNKCVELGMTPENVQWNRDSIPTSRKRKDDGPIVPANDLKAMAYP 128

  Fly   227 SNT----------TSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSIT--------NDEASSSSG 273
            ..:          .|....||..:||.   |...:.....:::|..|.        |.:.|..
Worm   129 DGSLFGKPRTIMDISTLSAKIKNILNE---DKGGIDPATKKMNTLEIADYALRKWRNLQRSEE-- 188

  Fly   274 SIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLL 338
              |:|.....|                 :..:..|::|:::.|..|..|.|.|..|.|.::....
Worm   189 --KMEKLDKLP-----------------VRQMFAIFEKQMIVVAEWLVQNPDFRLLSLEERYIYF 234

  Fly   339 QVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKECGYTEFYYHCVQIAQRMERISPRREEY 403
            :..|                       ::|                              ||.|.
Worm   235 KAMW-----------------------NMW------------------------------RRFER 246

  Fly   404 YLLKALLLANCDILLDDQSSLRAF---RDTIL--------NSLND-----VVYLLRHSSAVSHQQ 452
            :.:...:..|      |...:|.|   .|.||        :.:.|     |..:.|||.:..|.|
Worm   247 FEMSVKMFGN------DVVEIRKFAISNDQILTKEFTIDFSEITDVPNTTVQEMFRHSMSKMHHQ 305

  Fly   453 ---QLLLLLPS 460
               .||.|.||
Worm   306 VAKPLLELRPS 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	34/100 (34%)
ERR	NP_648183.3	NR_LBD	237..493	CDD:299703	44/251 (18%)
nhr-102	NP_506967.1	ZnF_C4	23..95	CDD:197701	29/71 (41%)
nhr-102	NP_506967.1	Hormone_recep	186..389	CDD:278530	37/211 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910