Protein Alignment ERR and Esr2

DIOPT Version :10

• Sequence 1: NP_648183.3
• Gene: ERR / 38912
• FlyBaseID: FBgn0035849
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_997590.1
• Gene: Esr2 / 13983
• MGIID: 109392
• Length: 567
• Species: Mus musculus
• Alignment Length: 540
• Identity: 160/540 - (29%)
• Similarity: 255/540 - (47%)
• Gaps: 131/540 - (24%)

  Fly    21 HIKQEVDTPSASCFSPSSKSTATQSGTNGLK-------SSPSV--------SPERQLCSST---- 66
            :::...:..:.:.:||:..:.:..|.|..|:       :||:|        ||....|.|:
Mouse    55 YVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYA 119

  Fly    67 ---TSLSCDLHNV--SLSNDGDSLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELRRL 126
               .|..|:..::  :|..:.::||       ...||.|..|...:.:|...|          ..
Mouse   120 EPQKSPWCEARSLEHTLPVNRETLK-------RKLGGSGCASPVTSPSAKRDA----------HF 167

  Fly   127 CLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMG 191
            |.||.|.|||:||||.|||.|||||||:|||:.:|.|||.|:|.|:|.|||:|||||.:||..:|
Mouse   168 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVG 232

  Fly   192 MLKEGVRLDRVRGGRQKYRRNPVSNSYQTMQLLYQSNTTSLCDVKILE-VLNSYEPDAL---SVQ 252
            |:|.|.|  |.|.|.:..||.  .::.:.:..|.::..||....::.| :|||..|:.|   .::
Mouse   233 MVKCGSR--RERCGYRIVRRQ--RSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLE 293

  Fly   253 TPPPQVHTT--SITNDEASSSSGSIKLESSVVTPNGTCIFQNNNNNDPNEILSVLSDIYDKELVS 315
            ..||.|..:  |:...|||                               ::..|:.:.|||||.
Mouse   294 AEPPNVLVSRPSMPFTEAS-------------------------------MMMSLTKLADKELVH 327

  Fly   316 VIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDE-------HL 373
            :|||||:||||::|.|.||::||:..|.|:|.:.|.:||:...|||.||.|:.:|.       |:
Mouse   328 MIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRSSEDPHWHV 392

  Fly   374 AK----------EC--GYTEFYYHCVQIAQRMERISPRREEYYLLKALLLANCDIL------LDD 420
            |:          :|  |..|.:...:....|...:..:.:||..:||::|.|..:.      .:.
Mouse   393 AQTKSAVPRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEA 457

  Fly   421 QSSLRAFRDTILNSLNDVVYLLRHSSAVSHQQQ------LLLLLPSLRQADDILRRFWRGIARDE 479
            :||.:...  :||::.|.:..:...|.:|.|||      ||:||..:|...:      :|:  :.
Mouse   458 ESSRKLTH--LLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISN------KGM--EH 512

  Fly   480 VITMK--------KLFLEML 491
            :::||        .|.||||
Mouse   513 LLSMKCKNVVPVYDLLLEML 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERR	NP_648183.3	NR_DBD_ERR	121..217	CDD:143544	52/95 (55%)
		NR_LBD	237..493	CDD:472173	82/300 (27%)
Esr2	NP_997590.1	ERbeta_N	31..144	CDD:463610	15/88 (17%)
		NR_DBD_ER	163..244	CDD:143545	50/92 (54%)
		NR_LBD_ER	282..535	CDD:132747	78/292 (27%)