DRSC/TRiP Functional Genomics Resources

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Protein Alignment ERR and Esr1

DIOPT Version :9

Sequence 1:NP_648183.3 Gene:ERR / 38912 FlyBaseID:FBgn0035849 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_001289460.1 Gene:Esr1 / 13982 MGIID:1352467 Length:599 Species:Mus musculus


Alignment Length:494 Identity:150/494 - (30%)
Similarity:246/494 - (49%) Gaps:55/494 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 SASCFSPSSKSTATQSGTNGLKSSP---SVSPE-RQLCSSTTSLSCDLH------NVSLSNDGD- 83
            |...:.|.|::.|..:  |.|.:.|   ||||. ..|......||..||      ...|.|:.. 
Mouse    80 SGIAYGPGSEAAAFSA--NSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSA 142

  Fly    84 -SLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELR--RLCLVCGDVASGFHYGVASCE 145
             :::.:|...............|....:|:......:.:..:  |.|.||.|.|||:||||.|||
Mouse   143 YAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCE 207

  Fly   146 ACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQ-KY 209
            .|||||||:|||:.:|.|||.|:|.|:|.|||:|||||.:||..:||:|.|:|.|| ||||. |:
Mouse   208 GCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDR-RGGRMLKH 271

  Fly   210 RRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGS 274
            :|       |...|..::...:..|::...:.    |..|.::.........|:|.|:       
Mouse   272 KR-------QRDDLEGRNEMGASGDMRAANLW----PSPLVIKHTKKNSPALSLTADQ------- 318

  Fly   275 IKLESSVVTPNGTCIFQNNNNNDP---NEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMK 336
              :.|:::......|:...:.:.|   ..::.:|:::.|:|||.:|.|||::|||.||.|:||:.
Mouse   319 --MVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVH 381

  Fly   337 LLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKEC--GYTEFYYHCVQIAQRMERISPR 399
            ||:.:|.|||.:.|.:||:...|||.||.::.:|.:..| |  |..|.:...:..:.|...::.:
Mouse   382 LLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK-CVEGMVEIFDMLLATSSRFRMMNLQ 445

  Fly   400 REEYYLLKALLLANCDILLDDQSSLRAFRD-----TILNSLND-VVYLLRHSSAVSHQQ-----Q 453
            .||:..||:::|.|..:.....|:|::..:     .:|:.:.| :::|:..:.....||     |
Mouse   446 GEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQ 510

  Fly   454 LLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLE 492
            |||:|..:|...:........:....|:.:..|.||||:
Mouse   511 LLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLD 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERRNP_648183.3 NR_DBD_ERR 121..217 CDD:143544 56/98 (57%)
NR_LBD 237..493 CDD:299703 70/272 (26%)
Esr1NP_001289460.1 Modulating (transactivation AF-1), mediates interaction with MACROD1. /evidence=ECO:0000250 1..188 21/109 (19%)
Interaction with DDX5, self-association. /evidence=ECO:0000250 35..178 21/99 (21%)
Required for interaction with NCOA1. /evidence=ECO:0000250 35..47
Oest_recep 42..185 CDD:366947 21/106 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..175 3/27 (11%)
NR_DBD_ER 184..265 CDD:143545 50/81 (62%)
Mediates interaction with DNTTIP2. /evidence=ECO:0000250 189..314 60/136 (44%)
Hinge 255..314 16/70 (23%)
Interaction with AKAP13. /evidence=ECO:0000250 266..599 77/305 (25%)
Self-association. /evidence=ECO:0000250 268..599 75/303 (25%)
NR_LBD_ER 314..551 CDD:132747 67/246 (27%)
Transactivation AF-2. /evidence=ECO:0000250 315..599 67/245 (27%)
ESR1_C 556..599 CDD:372285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..581
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835210
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.940

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