DRSC/TRiP Functional Genomics Resources

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Protein Alignment ERR and Esr1

DIOPT Version :10

Sequence 1:NP_648183.3 Gene:ERR / 38912 FlyBaseID:FBgn0035849 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_031982.1 Gene:Esr1 / 13982 MGIID:1352467 Length:599 Species:Mus musculus


Alignment Length:494 Identity:150/494 - (30%)
Similarity:246/494 - (49%) Gaps:55/494 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 SASCFSPSSKSTATQSGTNGLKSSP---SVSPE-RQLCSSTTSLSCDLH------NVSLSNDGD- 83
            |...:.|.|::.|..:  |.|.:.|   ||||. ..|......||..||      ...|.|:.. 
Mouse    80 SGIAYGPGSEAAAFSA--NSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSA 142

  Fly    84 -SLKGSGTSGGNGGGGGGGTSGGNATNASAGAGSGSVRDELR--RLCLVCGDVASGFHYGVASCE 145
             :::.:|...............|....:|:......:.:..:  |.|.||.|.|||:||||.|||
Mouse   143 YAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCE 207

  Fly   146 ACKAFFKRTIQGNIEYTCPANNECEINKRRRKACQACRFQKCLLMGMLKEGVRLDRVRGGRQ-KY 209
            .|||||||:|||:.:|.|||.|:|.|:|.|||:|||||.:||..:||:|.|:|.|| ||||. |:
Mouse   208 GCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDR-RGGRMLKH 271

  Fly   210 RRNPVSNSYQTMQLLYQSNTTSLCDVKILEVLNSYEPDALSVQTPPPQVHTTSITNDEASSSSGS 274
            :|       |...|..::...:..|::...:.    |..|.::.........|:|.|:       
Mouse   272 KR-------QRDDLEGRNEMGASGDMRAANLW----PSPLVIKHTKKNSPALSLTADQ------- 318

  Fly   275 IKLESSVVTPNGTCIFQNNNNNDP---NEILSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMK 336
              :.|:::......|:...:.:.|   ..::.:|:::.|:|||.:|.|||::|||.||.|:||:.
Mouse   319 --MVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVH 381

  Fly   337 LLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDEHLAKEC--GYTEFYYHCVQIAQRMERISPR 399
            ||:.:|.|||.:.|.:||:...|||.||.::.:|.:..| |  |..|.:...:..:.|...::.:
Mouse   382 LLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK-CVEGMVEIFDMLLATSSRFRMMNLQ 445

  Fly   400 REEYYLLKALLLANCDILLDDQSSLRAFRD-----TILNSLND-VVYLLRHSSAVSHQQ-----Q 453
            .||:..||:::|.|..:.....|:|::..:     .:|:.:.| :::|:..:.....||     |
Mouse   446 GEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQ 510

  Fly   454 LLLLLPSLRQADDILRRFWRGIARDEVITMKKLFLEMLE 492
            |||:|..:|...:........:....|:.:..|.||||:
Mouse   511 LLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLD 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERRNP_648183.3 NR_DBD_ERR 121..217 CDD:143544 56/98 (57%)
NR_LBD 237..493 CDD:472173 70/272 (26%)
Esr1NP_031982.1 Modulating (transactivation AF-1), mediates interaction with MACROD1. /evidence=ECO:0000250 1..188 21/109 (19%)
Interaction with DDX5, self-association. /evidence=ECO:0000250 35..178 21/99 (21%)
Required for interaction with NCOA1. /evidence=ECO:0000250 35..47
Oest_recep 42..185 CDD:460469 21/106 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..175 3/27 (11%)
NR_DBD_ER 184..265 CDD:143545 50/81 (62%)
Mediates interaction with DNTTIP2. /evidence=ECO:0000250 189..314 60/136 (44%)
Hinge 255..314 16/70 (23%)
Interaction with AKAP13. /evidence=ECO:0000250 266..599 77/305 (25%)
Self-association. /evidence=ECO:0000250 268..599 75/303 (25%)
NR_LBD_ER 314..551 CDD:132747 67/246 (27%)
Transactivation AF-2. /evidence=ECO:0000250 315..599 67/245 (27%)
ESR1_C 556..599 CDD:432757
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..581
Blue background indicates that the domain is not in the aligned region.

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