DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uxs and Uxs1

DIOPT Version :9

Sequence 1:	NP_648182.1	Gene:	Uxs / 38911	FlyBaseID:	FBgn0035848	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001355216.1	Gene:	Uxs1 / 67883	MGIID:	1915133	Length:	425	Species:	Mus musculus

Alignment Length:	443	Identity:	268/443 - (60%)
Similarity:	329/443 - (74%)	Gaps:	36/443 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TKKRLKIVAAIS-----LLLLLLVYLYRMASFCPSGKVAVSVPGVEEVQAKWPPTESPLQRSLQM 63
            :|..|::|::::     |||.:.::.|           |.||.|      .:......|.||:|
Mouse     3 SKGLLRLVSSVNRRRMKLLLGIALFAY-----------AASVWG------NFVNMSFLLNRSIQ- 49

  Fly    64 AYEEQSSLIREQKAELQRTRENLARLEEQVRSLQTSTPRKYPKVKYLNYKNRKRILITGGAGFVG 128
               |...|..|.|.|     |.:..|.|::|.|:.|..:|||.||:|:.|:||||||||||||||
Mouse    50 ---ENGELKIESKIE-----EIVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVG 106

  Fly   129 SHLVDDLMVQGHEVIVVDNFFTGRKRNVEHWLGHENFELIHHDIVNPLFIEIDEIYHLASPASPP 193
            |||.|.||:.||||.||||||||||||||||:||||||||:||:|.||:||:|:|||||||||||
Mouse   107 SHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPP 171

  Fly   194 HYMYNPVKTIKTNTMGTINVLGLAKRVMAKVLIASTSEVYGDPTVHPQPETYWGHVNPIGPRACY 258
            :|||||:||:||||:||:|:|||||||.|::|:||||||||||.||||.|.||||||||||||||
Mouse   172 NYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACY 236

  Fly   259 DEGKRVSETLSYAYAKQEKVQVRVARIFNTYGPRMHMNDGRVVSNFILQALRNETITVYGNGKQT 323
            ||||||:||:.|||.|||.|:|||||||||:||||||||||||||||||||:.|.:||||:|.||
Mouse   237 DEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQT 301

  Fly   324 RSFQYVSDLVDGMIALMASNYTQPVNLGNPVEQTIGEFAEIIKKLVGGPSVIKQSKAMEDDPQRR 388
            |:||||||||:|::|||.||.:.|||||||.|.||.|||::||.|||..|.|:.....:||||:|
Mouse   302 RAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKR 366

  Fly   389 KPDITRARQLLHWEPKVPLETGLQRTISYFRNELARSDRFQESSNKYFDTHTP 441
            ||||.:|:.:|.|||.||||.||.:.|.|||.||.     .:::|:|.....|
Mouse   367 KPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELE-----YQANNQYIPKPKP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uxs	NP_648182.1	WcaG	116..424	CDD:223528	231/307 (75%)
Uxs	NP_648182.1	UGD_SDR_e	116..419	CDD:187541	227/302 (75%)
Uxs1	NP_001355216.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838258
Domainoid	1	1.000	473	1.000	Domainoid score	I445
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41609
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1266
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S1822
OMA	1	1.010	-	-		QHG61048
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002011
OrthoInspector	1	1.000	-	-		oto92065
orthoMCL	1	0.900	-	-		OOG6_100713
Panther	1	1.100	-	-	LDO	PTHR43078
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1867
SonicParanoid	1	1.000	-	-		X1322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740