DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uxs and sqv-1

DIOPT Version :9

Sequence 1:	NP_648182.1	Gene:	Uxs / 38911	FlyBaseID:	FBgn0035848	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_501418.1	Gene:	sqv-1 / 177631	WormBaseID:	WBGene00005019	Length:	467	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	243/376 - (64%)
Similarity:	303/376 - (80%)	Gaps:	4/376 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TESPLQRSLQMAYEEQSSLIREQKAELQRTRENLARLEEQVRSLQTSTPRKYPKVKYLNYKNRKR 117
            |.|.|...:::..:|.||: |.:..:.:....|.|..:|.|..|.|:  :.:|.|:|.|.:.|||
Worm    77 TVSSLLERIKLLEDELSSM-RTRMDDAENREGNAANGDEIVAPLPTT--KSFPSVRYRNEETRKR 138

  Fly   118 ILITGGAGFVGSHLVDDLMVQGHEVIVVDNFFTGRKRNVEHWLGHENFELIHHDIVNPLFIEIDE 182
            ||||||||||||||||.||:.|||||.:||:|||||:|||||:||.|||::|||:|||.|:|:|:
Worm   139 ILITGGAGFVGSHLVDKLMLDGHEVIALDNYFTGRKKNVEHWIGHPNFEMVHHDVVNPYFVEVDQ 203

  Fly   183 IYHLASPASPPHYMYNPVKTIKTNTMGTINVLGLAKRVMAKVLIASTSEVYGDPTVHPQPETYWG 247
            |||||||||||||||||||||||||:||||:|||||||.|.||:||||||||||.||||||||||
Worm   204 IYHLASPASPPHYMYNPVKTIKTNTLGTINMLGLAKRVKATVLLASTSEVYGDPEVHPQPETYWG 268

  Fly   248 HVNPIGPRACYDEGKRVSETLSYAYAKQEKVQVRVARIFNTYGPRMHMNDGRVVSNFILQALRNE 312
            |||.|||||||||||||:|:|..||.|||.:::|:||||||:||||||||||||||||:|||:::
Worm   269 HVNTIGPRACYDEGKRVAESLMVAYNKQENIKIRIARIFNTFGPRMHMNDGRVVSNFIIQALQDK 333

  Fly   313 TITVYGNGKQTRSFQYVSDLVDGMIALMASNYTQPVNLGNPVEQTIGEFAEIIKKLV-GGPSVIK 376
            .||:||||.||||||||:|||||:|.||.|||:.|||:|||.|.|||:||.||:.|| |..|.|.
Worm   334 PITIYGNGTQTRSFQYVTDLVDGLIKLMNSNYSLPVNIGNPEEHTIGQFATIIRDLVPGSTSEIV 398

  Fly   377 QSKAMEDDPQRRKPDITRARQLLHWEPKVPLETGLQRTISYFRNELARSDR 427
            ..::.:||||:|:|||.||.:.:.|.|:|.::.||.:|:.|||.|:.|:.|
Worm   399 NLESQQDDPQQRRPDIRRAAEQISWAPQVHMKDGLLKTVDYFRAEIDRNKR 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uxs	NP_648182.1	WcaG	116..424	CDD:223528	223/308 (72%)
Uxs	NP_648182.1	UGD_SDR_e	116..419	CDD:187541	220/303 (73%)
sqv-1	NP_501418.1	UGD_SDR_e	137..441	CDD:187541	220/303 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160071
Domainoid	1	1.000	466	1.000	Domainoid score	I224
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41609
Inparanoid	1	1.050	507	1.000	Inparanoid score	I725
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S1822
OMA	1	1.010	-	-		QHG61048
OrthoDB	1	1.010	-	-		D289613at33208
OrthoFinder	1	1.000	-	-		FOG0002011
OrthoInspector	1	1.000	-	-		oto17646
orthoMCL	1	0.900	-	-		OOG6_100713
Panther	1	1.100	-	-	LDO	PTHR43078
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1867
SonicParanoid	1	1.000	-	-		X1322
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790