DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl7 and Adgrl2

DIOPT Version :10

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:XP_036019331.1 Gene:Adgrl2 / 99633 MGIID:2139714 Length:1494 Species:Mus musculus


Alignment Length:423 Identity:79/423 - (18%)
Similarity:143/423 - (33%) Gaps:110/423 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 GLKEELARFKPYIYFTYMDLQARVPLTDMAIIRDEFFDCDEMIYISDFNYFLEEVSIQIFNKCGL 170
            |....:|...|.|..:.....:||.|||..:......|.|        |||....|...:::..:
Mouse   747 GRNSTIAVNSPVISVSINKESSRVYLTDPVLFTLPHIDPD--------NYFNANCSFWNYSERTM 803

  Fly   171 I-VWFQDGKFWVTVDLFMEKQDYCLYRH--NFDSDFPKSMWIIRHRCTSHISPGSLEIL------ 226
            : .|...|...|..:   :.:..|...|  ||       ..::.||..:: ..|...:|      
Mouse   804 MGYWSTQGCKLVDTN---KTRTTCACSHLTNF-------AILMAHREIAY-KDGVHHLLLTVITW 857

  Fly   227 ---IITMICFVLTIAVYLYIKKL---RNVTGKCIVCCIVSRFIQCLIMILDHLNLLNGI------ 279
               :::::|..:.|..:.:.:.|   ||...|.:          |:.:.:.....|.||      
Mouse   858 VGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNL----------CINLFIAEFIFLIGIDKTKYT 912

  Fly   280 --CSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNA-------FVWSTAAIM 335
              |.......|||.:|:..|:.:.....:.:|..:...:.:.:...|.|       .|..:|||.
Mouse   913 IACPVFAGLLHFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAID 977

  Fly   336 TGSIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAIYIR 400
            ..|...|...|.:..:.:                   :|.:| ||...:...|:....:|...:.
Mouse   978 YKSYGTVQACWLHVDNYF-------------------IWSFI-GPVTFIILLNIIFLVITLCKMV 1022

  Fly   401 K----VKGGINKFTNEEEGRINC---INFDSQTY-----------LQFLRLSIVMGLTWIFNVIP 447
            |    :|...::..|....|: |   .|.|...|           |....|..::||||.|.:  
Mouse  1023 KHSNTLKPDSSRLENINNYRV-CDGYYNTDLPGYEDNKPFIKSWVLGAFALLCLLGLTWSFGL-- 1084

  Fly   448 YSARLHIFWEWVGIISEYFHSAF----GIVLFV 476
                  :|.....::..|..:||    |:.:|:
Mouse  1085 ------LFVNEETVVMAYLFTAFNAFQGLFIFI 1111

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:448329 23/110 (21%)
7tmB3_Methuselah-like 226..489 CDD:410632 54/300 (18%)
TM helix 2 251..271 CDD:410632 2/19 (11%)
TM helix 3 281..308 CDD:410632 5/26 (19%)
TM helix 4 321..341 CDD:410632 7/26 (27%)
TM helix 5 369..399 CDD:410632 6/29 (21%)
TM helix 6 422..449 CDD:410632 9/37 (24%)
TM helix 7 457..482 CDD:410632 5/24 (21%)
Adgrl2XP_036019331.1 Gal_Rha_Lectin_LPHN2 36..132 CDD:438702
OLF 143..399 CDD:470611
HormR 470..534 CDD:214468
GAIN 543..765 CDD:465137 4/17 (24%)
GPS 789..841 CDD:197639 11/61 (18%)
7tm_GPCRs 850..1130 CDD:475119 54/301 (18%)
TM helix 1 852..876 CDD:410628 2/23 (9%)
TM helix 2 885..906 CDD:410628 4/30 (13%)
TM helix 3 916..938 CDD:410628 5/21 (24%)
TM helix 4 957..973 CDD:410628 3/15 (20%)
TM helix 5 992..1015 CDD:410628 5/42 (12%)
TM helix 6 1066..1088 CDD:410628 8/29 (28%)
TM helix 7 1092..1117 CDD:410628 5/20 (25%)
Latrophilin 1129..1494 CDD:460538
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.