DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and ADGRG6

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_006715579.1	Gene:	ADGRG6 / 57211	HGNCID:	13841	Length:	1251	Species:	Homo sapiens

Alignment Length:	502	Identity:	98/502 - (19%)
Similarity:	164/502 - (32%)	Gaps:	128/502 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IPGCNYYDTVDISYIERQNDSYLYDDIEIPASLTGYYEFRQFGDGSITPIEKHLRACVCSVRPCI 88
            :||.|......|. :...|:||...|.|               .|.:.|:..
Human   688 LPGTNAISNFSIG-LPSNNESYFQMDFE---------------SGQVDPLAS------------- 723

  Fly    89 RICCPAKNFLANGKCDDGLKEELARFKPYIYFTYMDLQARVPLTDMAIIRDEFFDCDEMIYISDF 153
             :..| .|.|.|...:|.:   |.|...:.:|....|...|......::..........|.|.:.
Human   724 -VILP-PNLLENLSPEDSV---LVRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNL 783

  Fly   154 NYFLEEVSIQIFNKCGLIVWFQDGKFWVTVDLFMEKQ------DYCLYRHNFDSDFPKSMWIIRH 212
            .   :.|.|:|.:.....|......||   ||...|.      ..|:...  |||..:::.:..|
Human   784 K---DPVQIKIKHTRTQEVHHPICAFW---DLNKNKSFGGWNTSGCVAHR--DSDASETVCLCNH 840

  Fly   213 -----------RCTSHISPGSLEILI--------ITMICFVLTIAVYLYIKKLRNVTGKCIVCCI 258
                       |..|.:...:.::|.        |:.|....|:..|:..:|||.        ..
Human   841 FTHFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRR--------DY 897

  Fly   259 VSRFIQCLIMILDHLNLL------------NGICSPAGYSSHFFRMASNLWLSVISYHTWKVLTS 311
            .|:.:..|...|..||||            :|:|.......|||.:|:..|:.:.:.|.:..|..
Human   898 PSKILMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVK 962

  Fly   312 LNRVDPNYRFLRYNAFVWSTAAIMTGSIYIV----NQIW--------ENDPSKWNWLPLVGFIRC 364
            :.........|::....|...|::. |:.:.    |:::        :.|...|...|::.::.|
Human   963 VFNTYIRRYILKFCIIGWGLPALVV-SVVLASRNNNEVYGKESYGKEKGDEFCWIQDPVIFYVTC 1026

  Fly   365 SVKDWHPSVWIYISGPSLALSTFNVAMFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQ 429
                         :|....:...|:|||.:..:.|....|..:..|..||...|..:..|.|:|
Human  1027 -------------AGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFL- 1077

  Fly   430 FLRLSIVMGLTWIFNV-------IPYSARLHIFWEWVGIISEYFHSA 469
                   :|:||.|..       ||:.....||....|:....||.|
Human  1078 -------LGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCA 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	35/203 (17%)
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001
		LamG	154..338	CDD:304605
		GPS	802..847	CDD:280071	10/49 (20%)
		7tm_4	864..1111	CDD:304433	56/276 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810