DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and Adgre4

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_631877.2	Gene:	Adgre4 / 52614	MGIID:	1196464	Length:	689	Species:	Mus musculus

Alignment Length:	282	Identity:	61/282 - (21%)
Similarity:	107/282 - (37%)	Gaps:	72/282 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 LIITMICFVLTIAVYLYIKKLRNVTGKCIVCCIVSRFIQCLI-MILDHLNLLNGI--------CS 281
            |.::::|..|....:|..:.::|.:        .:..:|..| :.|..|..|.||        ||
Mouse   354 LSLSLLCLFLAAITFLLCRPIQNTS--------TTLHLQLSICLFLADLLFLTGINRTKPKVLCS 410

  Fly   282 PAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNY--------RFL---RYN--AFVWSTAA 333
            ......|:..:||.:|:.:...|.:  ||..|....||        ||:   .|.  ||:.:.:|
Mouse   411 IIAGMLHYLYLASFMWMFLEGLHLF--LTVSNLKVANYSNSGRFKKRFMYPVGYGLPAFIVAVSA 473

  Fly   334 IMTGSIYIVNQIWENDPSKWNWLPL-VGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAI 397
            |.....|        ......||.| .|||           |.:: ||:.|:...|:..:.|...
Mouse   474 IAGHKNY--------GTHNHCWLSLHRGFI-----------WSFL-GPAAAIILINLVFYFLIIW 518

  Fly   398 YIRKVKGGINK-FTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSARLHIFWE---W 458
            .:|.....:|| .:..::.::       .|:...::| .|:|.:|       ...|.||.|   .
Mouse   519 ILRSKLSSLNKEVSTLQDTKV-------MTFKAIVQL-FVLGCSW-------GIGLFIFIEVGKT 568

  Fly   459 VGIISEYFHSAFGIVLFVLLVL 480
            |.:|..|..:...::..||:.:
Mouse   569 VRLIVAYLFTIINVLQGVLIFM 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804
Adgre4	NP_631877.2	EGF_CA	77..>105	CDD:214542
		GAIN	<214..262	CDD:293098
		GPS	290..332	CDD:280071
		7tm_4	343..588	CDD:304433	60/278 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810