Protein Alignment mthl7 and Adgrf2

DIOPT Version :10

• Sequence 1: NP_648181.2
• Gene: mthl7 / 38910
• FlyBaseID: FBgn0035847
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: XP_017173054.1
• Gene: Adgrf2 / 435529
• MGIID: 2182728
• Length: 673
• Species: Mus musculus
• Alignment Length: 351
• Identity: 72/351 - (20%)
• Similarity: 126/351 - (35%)
• Gaps: 103/351 - (29%)

  Fly   188 EKQDYCLYRHNFDS--DFPKSMWIIRH------RCTSH---------ISPGSLEILIIT------ 229
            |::..|:..|:.:|  |:.....|..:      ||..:         :||.:||..::|
Mouse   324 ERKSQCVGWHSLESRWDWRACKTIQENSRQAVCRCRPNKLYTSFSILMSPNTLESPVLTYITYIG 388

  Fly   230 --------MICFVLTIAVYLYIKK----------LRNVTGKCIVC---CIVSRFIQCLIMILDHL 273
                    :||..:.:.|:..:.|          :.|:....::.   .||:.|:..  .:|.|
Mouse   389 LGISICSLIICLAIEVLVWSQVTKTEISYLRHLCIANIAATLLMADAWFIVASFLSG--PVLHH- 450

  Fly   274 NLLNGICSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNAFVWSTAAIMTGS 338
               || |..|.:..|||      :|||..:...|.|..|..:...:..|..:..|.|..::..|.
Mouse   451 ---NG-CVAATFFVHFF------YLSVFFWMLAKALLILYGILIVFHTLPKSCLVASLFSVGYGC 505

  Fly   339 --IYIVNQIWENDPSK--------W-NW---LPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNV 389
              :..:..:...:|.|        | ||   ..|:.|:                .|:||:...|
Mouse   506 PLVIAIITLAVTEPGKGYLRPEACWLNWDMTKALLAFV----------------VPALAIVVVN- 553

  Fly   390 AMFALTAIYIRKVKGGINKFTNEEEGRI--NCINFDSQTYLQFLRLSIVMGLTWIFNVIP----Y 448
             :..:|.:.|:..:..|.....:|...|  .|.|....|.|        :||||.|.:..    :
Mouse   554 -LITVTMVIIKTQRAAIGSSMFQEVRAIVRICKNIAILTPL--------LGLTWGFGIATVINGH 609

  Fly   449 SARLHIFWEWVGIISEYFHSAFGIVL 474
            |...||.:..:..:..:|...||.:|
Mouse   610 SLAFHIIFSLLNALQGFFILLFGTIL 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:448329	6/33 (18%)
		7tmB3_Methuselah-like	226..489	CDD:410632	60/296 (20%)
		TM helix 2	251..271	CDD:410632	3/22 (14%)
		TM helix 3	281..308	CDD:410632	7/26 (27%)
		TM helix 4	321..341	CDD:410632	4/21 (19%)
		TM helix 5	369..399	CDD:410632	5/29 (17%)
		TM helix 6	422..449	CDD:410632	7/30 (23%)
		TM helix 7	457..482	CDD:410632	4/18 (22%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:470616	7/46 (15%)
		7tmB2_GPR111_115	378..644	CDD:320660	60/297 (20%)
		TM helix 1	380..405	CDD:320660	3/24 (13%)
		TM helix 2	420..442	CDD:320660	3/21 (14%)
		TM helix 3	454..481	CDD:320660	10/32 (31%)
		TM helix 4	495..515	CDD:320660	3/19 (16%)
		TM helix 5	535..564	CDD:320660	8/46 (17%)
		TM helix 6	580..606	CDD:320660	10/33 (30%)
		TM helix 7	611..636	CDD:320660	6/25 (24%)