DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl7 and mthl2

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_788462.2	Gene:	mthl2 / 38636	FlyBaseID:	FBgn0035623	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	172/507 - (33%)
Similarity:	264/507 - (52%)	Gaps:	55/507 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VIFCTVLLLIFTN--NSNADIPGCNYYDTVDISYIER-QNDSYLYDDIEIPASLTGYYEFRQFGD 67
            ::..::|:....|  :|:|:|..|::|||||||..:| .|.||||:.:.|||.||..|||:...:
  Fly     8 LLSASILIYFLLNLQSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLAN 72

  Fly    68 GSITPIEKHLRACVCSVRPCIRICCPAKNFLANGKCDDGLKEELARFKPYIYFTYMDLQARVPLT 132
            |....:..|:|.|||.:|.|:|.|||..:.:..|:|...:..|....        :|....|.|.
  Fly    73 GDKEQVPSHVRGCVCKLRTCVRFCCPHDHIMDMGECYANMTTEENEL--------LDPMLNVTLD 129

  Fly   133 DMAIIRDEF-------FD----CDEMIYISDFNYFLEEVSIQIFNKCGLIVWFQDGKFWVTVD-L 185
            |.::::..:       :|    ||:|.|: |....::|.::           |::|:.....| :
  Fly   130 DGSVVQRHYKKELMVQWDLPKPCDDMFYL-DNRDIMDEYTL-----------FENGRLLRHYDQV 182

  Fly   186 FMEKQDYCLYRHNFDSDFPKSMWIIRHRCTSHISP---GSLEILIITMICFVLTIAVYLYIKKLR 247
            :::|.:|||....|......|:.||.|.|.  |.|   |...::|.::||.||||||||.:|||.
  Fly   183 YLDKSEYCLQHRTFGEGNNNSIRIIPHNCL--ILPSRTGQTVVMITSLICLVLTIAVYLCVKKLM 245

  Fly   248 NVTGKCIVCCIVSRFIQCLIMILDHLNLLNGICSPAGYSSHFFRMASNLWLSVISYHTWKVLT-- 310
            |:.|||.:|.::..|...|.::||...|....|..||:..:||.||:..|||:||.|.||.||
  Fly   246 NLEGKCFICYMMCLFFGYLFLLLDLWELSLDFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNP 310

  Fly   311 --SLNRVDPNYRFLRYNAFVWSTAAIMTGSIYIVNQIWENDPSKWNWLPLVGFI-RCSV--KDWH 370
              |:| :.....||.|:.|.|:....:||..|:.:.:..|:    .|.|.||.. .|.:  |.|
  Fly   311 CASMN-IRSERAFLLYSCFAWAMPLALTGVTYLADNVVNNE----EWQPRVGDEGHCWIYTKSW- 369

  Fly   371 PSVWIYISGPSLALSTFNVAMFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQFLRLSI 435
             |..:|..||.:.|..||:.||.|||.:|...|..:.|.. ..||||..:|.|.|.|.|||.|..
  Fly   370 -SAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKIA-RNEGRIQKLNSDKQNYTQFLLLFT 432

  Fly   436 VMGLTWIFNVIPYSARLHIFWEWVGIISEYFHSAFGIVLFVLLVLKRSTWTL 487
            |||::|.|.:..|..:....|..:.::::||:.:.|:::|||.:|:|.|..|
  Fly   433 VMGMSWSFEIFSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRKTLVL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	60/199 (30%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:284145	60/199 (30%)
mthl2	NP_788462.2	7tm_4	221..>395	CDD:304433	70/180 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980