DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl7 and Adgrg5

DIOPT Version :9

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:NP_001139444.1 Gene:Adgrg5 / 382045 MGIID:2685955 Length:524 Species:Mus musculus


Alignment Length:542 Identity:94/542 - (17%)
Similarity:188/542 - (34%) Gaps:199/542 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LIFTNNSNADIPGCNYYDT--VDISYIERQNDSYLYDDIEIPASLTGYYEFRQFGDGSITPIEKH 76
            |:|  ..:.|.||.:...|  .::|.:...:      .::.||.||                   
Mouse    76 LVF--KLSCDFPGLSLSSTTLTNVSQVRAPH------AMQFPAELT------------------- 113

  Fly    77 LRACVCSVRPC-IRICCPAKNFLANGKCDDGLKEELARFKPYIYFTYMDLQARVPLTDMAIIRDE 140
            ..|||.| ||. :|:.| ...|.|:...||   ...:....|:....:|.:   |:.::      
Mouse   114 KGACVTS-RPAELRLIC-IYFFTAHLFQDD---RNSSLLNNYVLGAQLDHR---PVNNL------ 164

  Fly   141 FFDCDEMIYISDF-NYFLEEVSIQ-IFNKCGLI-----VWFQDGKFWVTVDLFMEKQDYCLYRHN 198
                .:.:.||.: |..||..::. :|.|.|..     .|..:|.:                   
Mouse   165 ----QKPVNISFWHNRSLEGYTVSCVFWKEGASKSSWGAWSPEGCY------------------- 206

  Fly   199 FDSDFPKSMWIIRHRCTSHIS-------------PGSLEILI---------ITMICFVLTIAVYL 241
              ::.|.:..::.| | :|::             |..|::.:         |:::..:|||.:|.
Mouse   207 --TEQPSATQVLCH-C-NHLTYFAVLMQLSGDPVPAELQVPLEYISFVGCSISIVASLLTILLYA 267

  Fly   242 YIKKLRNVTGKCIVCCIVSRFIQCLIMILDHLNLLNG----------ICSPAGYSSHFFRMASNL 296
            ..:|..:.|.:      :...:...:::|:...||:.          :|.......|:..::|..
Mouse   268 QSRKQSDSTTR------IHMNLNGSVLLLNVTFLLSSQMTLPTMPRPVCKVLAAVLHYALLSSLT 326

  Fly   297 WLSVISYHTWKVLTSLNRVDPNYRFLRYNAFV-----------WSTAAIMT-------GSIY--- 340
            |:::..::.:   ..|.||        |||::           |...|::.       .|:|   
Mouse   327 WMAIEGFNLY---LFLGRV--------YNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYGPC 380

  Fly   341 --IVNQIWENDPSKWN----WL--PLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAI 397
              .:::..||.....|    |:  |:|          |.   |.:.|.....|.||:.:.| .|:
Mouse   381 VTSLSKSQENGTGFQNVSMCWIRSPMV----------HS---ILVMGYGGFTSLFNLVVLA-WAL 431

  Fly   398 YI----RKVKGGINKFTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSA----RLHI 454
            :|    |..:..::.:...:...:             |.|::::|.||......:..    :|.:
Mouse   432 WILCRLRAREKALSPWAYRDTAMV-------------LGLTVLLGTTWTLAFFSFGVFLLPQLFL 483

  Fly   455 FWEWVGIISEYFHSAFGIVLFV 476
            |        ..|:|.:|..||:
Mouse   484 F--------TIFNSLYGFFLFL 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:299804 33/196 (17%)
Adgrg5NP_001139444.1 GPS 184..228 CDD:366827 9/66 (14%)
7tm_GPCRs 242..514 CDD:391938 52/308 (17%)
TM helix 1 244..268 CDD:341315 5/23 (22%)
TM helix 2 277..298 CDD:341315 3/26 (12%)
TM helix 3 311..333 CDD:341315 3/21 (14%)
TM helix 4 353..369 CDD:341315 2/15 (13%)
TM helix 5 405..428 CDD:341315 8/35 (23%)
TM helix 6 449..474 CDD:341315 5/37 (14%)
TM helix 7 478..503 CDD:341315 7/28 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.