Protein Alignment mthl7 and mthl8

DIOPT Version :10

• Sequence 1: NP_648181.2
• Gene: mthl7 / 38910
• FlyBaseID: FBgn0035847
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 97/533 - (18%)
• Similarity: 177/533 - (33%)
• Gaps: 182/533 - (34%)

  Fly     8 FCTVLLLIFTNNSNAD--------IPGCNYYDTVDISYIERQNDSYLYDDIEIPASLTGYYEFRQ 64
            ||.:.:|:..:.::..        .| |.:.||.:|:.....:..::::...||......|:| .
  Fly     4 FCILGVLLILSGTHCSWGFHEETHYP-CAFIDTANITGSYGLDGPFVHNWTVIPRHFVAVYDF-V 66

  Fly    65 FGDGSITPIEKHLRACVCSVRPCIRICCPAKNFLANGKCDDGLKEELARFKPYIYFTYMDLQAR- 128
            ..:|...|..:|||||||..:||:||||              |:.|       ||    ||:.|
  Fly    67 IENGIRIPASRHLRACVCKTKPCVRICC--------------LRGE-------IY----DLEKRQ 106

  Fly   129 --VPLTDMAIIRDEFFDCDEMIYISDFNYFLEEVSIQIFNKCGLIVWFQDGKFWVTVDLFMEKQD 191
              ||:..::.:...                 ..:.:::.|....:|..|. :|.:.|:...|...
  Fly   107 CLVPVAGVSSLPSH-----------------SHMEVELGNGSLRLVKLQP-RFSIHVETPCEHMK 153

  Fly   192 YCL----YRHNFDSDFPKSMWII--------------RHRCTSHISPGSLE-------------- 224
            ...    |.|          |.:              :|.|.:.:..|:..
  Fly   154 AVTKGSEYVH----------WTLHENGTISHRGHIFSKHYCFTPLLHGNSTWEWQPLACAPEKLY 208

  Fly   225 ------------ILIITMICFVLTIAVYLYIKKLRN----VTGKCIVCCIVSRFIQCLIMILDHL 273
                        .|:|.::...:.:.|||...::||    |..|....|::..:     .:|.:|
  Fly   209 FVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNSFYGVAIKAYAICMILGY-----ALLAYL 268

  Fly   274 NLLNGICSPAGYSSHFFRMASNLWLS--VISYHT----------------------WKVLTSLNR 314
            .|.|    ||..|:...|:..:|.|.  |:|::.                      |.:.|.:..
  Fly   269 TLHN----PANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWLIFTPIVL 329

  Fly   315 VDPNYRFLRYNAFVWSTAAIMTGSIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISG 379
            |...:.|  :..|.:..:.::.|.    :..| .||..|                  ||.||...
  Fly   330 VAVGWSF--FVGFSYYGSRLIFGG----DTCW-FDPRNW------------------SVMIYFYA 369

  Fly   380 PSLALSTFNVAMFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFN 444
            |.......:...:.|:.||||      ::...|.|.....|  :...:..|.:......:.|:..
  Fly   370 PVFVACAISGFFYVLSQIYIR------DQPDIETEKSFESI--EKNRFKSFWKYFGYTAVVWVVC 426

  Fly   445 VIPYSARLHIFWE 457
            :..::  .:.:||
  Fly   427 ICSFA--FNYYWE 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:448329	42/207 (20%)
		7tmB3_Methuselah-like	226..489	CDD:410632	49/260 (19%)
		TM helix 2	251..271	CDD:410632	2/19 (11%)
		TM helix 3	281..308	CDD:410632	9/50 (18%)
		TM helix 4	321..341	CDD:410632	3/19 (16%)
		TM helix 5	369..399	CDD:410632	7/29 (24%)
		TM helix 6	422..449	CDD:410632	2/26 (8%)
		TM helix 7	457..482	CDD:410632	1/1 (100%)
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	44/225 (20%)
		7tm_GPCRs	213..475	CDD:475119	49/269 (18%)
		TM helix 1	214..238	CDD:410628	4/23 (17%)
		TM helix 2	248..269	CDD:410628	4/25 (16%)
		TM helix 5	360..383	CDD:410628	6/40 (15%)
		TM helix 6	409..431	CDD:410628	2/21 (10%)
		TM helix 7	434..465	CDD:410628	2/4 (50%)