DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and Dh44-R1

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	76/397 - (19%)
Similarity:	143/397 - (36%)	Gaps:	119/397 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NYYDTVDIS----YIERQNDSYLYDDIEIPASLTGYYEFRQFGDGS---ITPIEKHLRACVCSVR 85
            |:.|:|:.|    .::..|...:.:.:|:...:..:.|...:|:.|   :|..:..|
  Fly     5 NHIDSVNASGSDPLLDLHNLDGIGESVELQCLVQEHIEASTYGNDSGHCLTQFDSIL-------- 61

  Fly    86 PCIRICCP--AKNFLANGKCDDGLK-------EELARF----KPYIYFTYMDLQARVPLTDMAII 137
                 |.|  |:..||..:|.|.|:       :...||    ..:..:|..|..|.:|..:....
  Fly    62 -----CWPRTARGTLAVLQCMDELQGIHYDSSKNATRFCHANGTWEKYTNYDACAHLPAPESVPE 121

  Fly   138 RDEFFDCDEMIYISDFNYFLEEVSIQIFNKCGLIV--WFQDGKFWVTVDLFMEKQDYCLYRHNFD 200
            .:...:...:||.  ..|.|..||:.:    .|||  :|              |:..||
  Fly   122 FEVIVELPTIIYY--IGYTLSLVSLSL----ALIVFAYF--------------KELRCL------ 160

  Fly   201 SDFPKSMWIIRHRCTSHISPGSLEILIITMICFVLTIAVYLYIKKLRNVTGKCIVCCIVSRFIQC 265
                        |.|.|.:  .....|::.:.::|.::|.:   .:|:..|.||  .:::.|
  Fly   161 ------------RNTIHAN--LFFTYIMSALFWILLLSVQI---SIRSGVGSCI--ALITLF--- 203

  Fly   266 LIMILDHLNLLNGICSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNAFVWS 330
                                  |||.:.:..|:.|...:.:.::......| |.||..|.:..|.
  Fly   204 ----------------------HFFTLTNFFWMLVEGLYLYMLVVKTFSGD-NLRFNIYASIGWG 245

  Fly   331 TAA--IMTGSIYIVNQIWENDPSKWNWLPLVGFIRCS-VKDWHPSVWIYISGPSLALSTFNVAMF 392
            ..|  ::|.::.....:..:.|.|:.       |.|. :::.|.. ||| .||..|:...|:. |
  Fly   246 GPALFVVTWAVAKSLTVTYSTPEKYE-------INCPWMQETHVD-WIY-QGPVCAVLIINLT-F 300

  Fly   393 ALTAIYI 399
            .|..:::
  Fly   301 LLRIMWV 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	38/207 (18%)
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	14/72 (19%)
		7tmB1_DH_R	126..394	CDD:320391	51/263 (19%)
		TM helix 1	129..153	CDD:320391	9/29 (31%)
		TM helix 2	162..183	CDD:320391	4/22 (18%)
		TM helix 3	197..219	CDD:320391	7/48 (15%)
		TM helix 4	238..254	CDD:320391	3/15 (20%)
		TM helix 5	279..302	CDD:320391	9/25 (36%)
		TM helix 6	327..349	CDD:320391
		TM helix 7	356..381	CDD:320391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840