DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and Adgre1

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	83/458 - (18%)
Similarity:	170/458 - (37%)	Gaps:	142/458 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NFLANG-KCDDG---LKEELARFKP---YIYFTYMDLQARVPLTDMAIIRDEFFDCDEMIY---- 149
            |..|.| |.|.|   :||..:...|   ::.|.:||          :::.:.||:..:..:
  Rat   503 NLKARGDKMDVGCFIIKESESTGTPGVAFVSFAHMD----------SVLDERFFEDGQASWKLRM 557

  Fly   150 -------------ISDFN----YFLEEVSIQIFNKCGLIV-W---FQDGKFWV-----TVDLFME 188
                         ..||:    |.|:.:..:..::..:.| |   .:||: |.     ||:. .|
  Rat   558 NSHVVGGTVTGERKEDFSKPIVYTLQHIQPKQKSERSICVSWNTDVEDGR-WTPSGCETVEA-SE 620

  Fly   189 KQDYC-----------LYRHNFDSDFPKSMWIIRHRCTSHISPGSLEILIITMICFVLTIAVYLY 242
            ....|           :.......:|  |::||.:..|           :|:::|..|.||.:|.
  Rat   621 THTVCSCNRMTNLAIIMASGELTMEF--SLYIISYVGT-----------VISLVCLALAIATFLL 672

  Fly   243 IKKLRNVTGKCIVCCIVSRFIQ---CLIMILDHLNLLNGI--------CSPAGYSSHFFRMASNL 296
            .:.::|          .:.::.   |:.:.|..:..|.||        |:......|:..:|...
  Rat   673 FRAVQN----------HNTYLHLHLCVCLFLAKILFLTGIDKTDNQTACAIIAGFLHYLFLACFF 727

  Fly   297 WLSVISYHTWKVLTSLNRVD----PNYRFLRYNAFVWS---TAAIMTGSIY-----IVNQIWEND 349
            |:.|.:...:.::.:|..|:    .|.:.|...||.:.   ...|::.:::     :.|:.|.|.
  Rat   728 WMLVEAVMLFLMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVVVVIISATVHPWGYGMHNRCWLNT 792

  Fly   350 PSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAIYIRKVKGGINKFTNE-E 413
            .:        |||           |.:: ||...:.|.|.|:.|.|...:|:....:|...:: :
  Rat   793 ET--------GFI-----------WSFL-GPVCMIITINSALLAWTLWVLRQKLCSVNSEVSKLK 837

  Fly   414 EGRINCINFDSQTYLQFLRLSIVMGLTW---IFNVIPYSARLHIFWEWVGIISEYFHSAFGIVLF 475
            :.|:......:|.:        ::|.:|   ||.:.|.::.:...:..:..:    ..||..::.
  Rat   838 DTRLLTFKAIAQIF--------ILGCSWVLGIFQIGPLASIMAYLFTTINSL----QGAFIFLIH 890

  Fly   476 VLL 478
            .||
  Rat   891 CLL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	31/165 (19%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..>109	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..255	CDD:214542
		cEGF	245..275	CDD:289433
		EGF_CA	272..>301	CDD:214542
		EGF_CA	319..359	CDD:284955
		Cell attachment site. /evidence=ECO:0000255	507..509		0/1 (0%)
		GPS	592..641	CDD:197639	9/50 (18%)
		7tm_2	646..886	CDD:278432	53/294 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810