DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and ADGRF1

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_722582.2	Gene:	ADGRF1 / 266977	HGNCID:	18990	Length:	910	Species:	Homo sapiens

Alignment Length:	370	Identity:	76/370 - (20%)
Similarity:	142/370 - (38%)	Gaps:	89/370 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 NYFLEEVSIQIFNK---------CGLIVWFQDGKFW--VTVDLFMEKQD----YCLYRHNF---- 199
            ||.:.||.: .|:|         |  :.|......|  ....|..|.||    .|.:..:|
Human   512 NYSINEVFL-FFSKIESNLSQPHC--VFWDFSHLQWNDAGCHLVNETQDIVTCQCTHLTSFSILM 573

  Fly   200 -----DSDFPKSMWIIRHRCTSHISPGSLEILIITMICFVLTIAVYLYIKKLRNVTGKCIVCCIV 259
                 .:.||...||.  .....||.|||      ::|.::....:..|||.:....:.|  |:|
Human   574 SPFVPSTIFPVVKWIT--YVGLGISIGSL------ILCLIIEALFWKQIKKSQTSHTRRI--CMV 628

  Fly   260 SRFIQCLI--------MILDHLNLLNGICSPAGYSSHFFRMASNLWLSVIS-YHTWKVLTSLNRV 315
            :..:..||        ..:|.....:|:|:.|.:.:|||.::...|:.::. ...::::...:.:
Human   629 NIALSLLIADVWFIVGATVDTTVNPSGVCTAAVFFTHFFYLSLFFWMLMLGILLAYRIILVFHHM 693

  Fly   316 DPNYRF-----LRYNAFVWSTAAIMTGSIYIVNQIWENDPSKW-NW----LPLVGFIRCSVKDWH 370
            ..:...     |.|...:  ..:::|.::...:..::.....| ||    .||:.|:
Human   694 AQHLMMAVGFCLGYGCPL--IISVITIAVTQPSNTYKRKDVCWLNWSNGSKPLLAFV-------- 748

  Fly   371 PSVWIYISGPSLALSTFN--VAMFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQFLRL 433
                    .|:||:...|  |.:..||.:: |...|  .:.:.:::..|..:.      ...|.|
Human   749 --------VPALAIVAVNFVVVLLVLTKLW-RPTVG--ERLSRDDKATIIRVG------KSLLIL 796

  Fly   434 SIVMGLTWIFNV--IPYSARL--HIFWEWVGIISEYFHSAFGIVL 474
            :.::||||.|.:  |..|..|  |:.:..:.....:|...|||:|
Human   797 TPLLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGILL 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	19/83 (23%)
ADGRF1	NP_722582.2	SEA	154..>215	CDD:279699
		GPS	532..572	CDD:280071	9/41 (22%)
		7tm_4	582..834	CDD:304433	56/288 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900