DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl7 and ADGRL1

DIOPT Version :9

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:XP_016881964.1 Gene:ADGRL1 / 22859 HGNCID:20973 Length:1506 Species:Homo sapiens


Alignment Length:389 Identity:75/389 - (19%)
Similarity:142/389 - (36%) Gaps:109/389 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 ARVPLTDMAIIRDEFFDCDEMIYISDFNYFLEEVSIQIFNKCGLIVWFQDGKFWVTVDLFMEKQD 191
            :||.|.|..|.        .:.::.|.|:|....|...:::..::      .:|.|....:.:.:
Human   785 SRVFLMDPVIF--------TVAHLEDKNHFNANCSFWNYSERSML------GYWSTQGCRLVESN 835

  Fly   192 ------YCLYRHNFDSDFPKSMWIIRHRCTSHISPGSL-EIL---------IITMICFVLTIAVY 240
                  .|.:..||       ..::.||   .|..|.: |:|         :|:::|..:.|:.:
Human   836 KTHTTCACSHLTNF-------AVLMAHR---EIYQGRINELLLSVITWVGIVISLVCLAICISTF 890

  Fly   241 LYIKKL---RNVTGKCIVCCIVSRFIQCLIMILDHLNLLNGI--------CSPAGYSSHFFRMAS 294
            .:::.|   ||...|.:          |:.:.|..|..|.||        |.......|:|.:|:
Human   891 CFLRGLQTDRNTIHKNL----------CINLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAA 945

  Fly   295 NLWLSVISYHTWKVLTSLNRVD---PNYRFLR---YNAFVWSTAAIMTGSIYIVNQIWENDPSKW 353
            ..||.:...|.:.:|..:...:   ..|.:|.   :.|.|...||.:....|        ...|.
Human   946 FSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSY--------GTEKA 1002

  Fly   354 NWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAIY--IRKVKGGINKFTNEEEGR 416
            .||.:..:.          :|.:| ||...:...|: :|.:..::  ||.     :.....:..|
Human  1003 CWLRVDNYF----------IWSFI-GPVSFVIVVNL-VFLMVTLHKMIRS-----SSVLKPDSSR 1050

  Fly   417 INCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSARLHIFWEWVGIISEYFHSAF----GIVLFV 476
            ::  |..|.. |..:.|..::||||.|.:        :|.....::..|..:.|    |:.:||
Human  1051 LD--NIKSWA-LGAIALLFLLGLTWAFGL--------LFINKESVVMAYLFTTFNAFQGVFIFV 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:299804 15/92 (16%)
ADGRL1XP_016881964.1 Gal_Lectin 48..128 CDD:396628
OLF 143..399 CDD:413369
PHA03247 <399..503 CDD:223021
HormR 484..547 CDD:214468
GAIN 557..782 CDD:406802
GPS 806..858 CDD:197639 9/67 (13%)
7tmB2_Latrophilin-1 865..1122 CDD:320673 57/285 (20%)
TM helix 1 868..892 CDD:320673 3/23 (13%)
TM helix 2 901..922 CDD:320673 6/30 (20%)
TM helix 3 932..954 CDD:320673 5/21 (24%)
TM helix 4 973..989 CDD:320673 4/15 (27%)
TM helix 5 1008..1031 CDD:320673 6/34 (18%)
TM helix 6 1058..1080 CDD:320673 8/30 (27%)
TM helix 7 1084..1109 CDD:320673 5/20 (25%)
Latrophilin 1121..1506 CDD:396778
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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