DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl7 and ADGRF5

DIOPT Version :10

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:XP_005248949.1 Gene:ADGRF5 / 221395 HGNCID:19030 Length:1386 Species:Homo sapiens


Alignment Length:355 Identity:68/355 - (19%)
Similarity:120/355 - (33%) Gaps:114/355 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 WVTVDLFMEKQD----YCLYRH--NF------DSDFPKSMWIIRHRCTSHISPGSLEILIITMIC 232
            |.:...::|:.|    .|:..|  :|      ||..|.|:..|.....|::..| ..||.:. .|
Human  1008 WDSSGCYVEEGDGDNVTCICDHLTSFSILMSPDSPDPSSLLGILLDIISYVGVG-FSILSLA-AC 1070

  Fly   233 FVLTIAVYLYIKKLRN--VTGKCIV-----CCIVSRFIQCLIMILDHLNLL-NGICSPAGYSSHF 289
            .|:...|:..:.|.|.  :...|||     ..:.:.:...:..|.|:..:| ...|..|.:..||
Human  1071 LVVEAVVWKSVTKNRTSYMRHTCIVNIAASLLVANTWFIVVAAIQDNRYILCKTACVAATFFIHF 1135

  Fly   290 FRMASNLWLSVI---------------SYHTWKVLT--------------SLNRVDPNYRFLRYN 325
            |.::...|:..:               |..|.|.:.              :|....|...:.|.|
Human  1136 FYLSVFFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCLGYGCPLAISVITLGATQPREVYTRKN 1200

  Fly   326 AFVWSTAAIMTGSIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVA 390
            . .|..              ||:..:      |:.|                :.|:|.:...|: 
Human  1201 V-CWLN--------------WEDTKA------LLAF----------------AIPALIIVVVNI- 1227

  Fly   391 MFALTAIYIRKV-KGGI-NKFTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSARLH 453
              .:|.:.|.|: :..| :|...:|:..:..|:.....      |:.::||||.|.:.......:
Human  1228 --TITIVVITKILRPSIGDKPCKQEKSSLFQISKSIGV------LTPLLGLTWGFGLTTVFPGTN 1284

  Fly   454 IFWEWVGIISEYFHSAFGIV-----LFVLL 478
            :          .||..|.|:     ||:||
Human  1285 L----------VFHIIFAILNVFQGLFILL 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:448329 11/45 (24%)
7tmB3_Methuselah-like 226..489 CDD:410632 54/297 (18%)
TM helix 2 251..271 CDD:410632 4/24 (17%)
TM helix 3 281..308 CDD:410632 7/41 (17%)
TM helix 4 321..341 CDD:410632 3/19 (16%)
TM helix 5 369..399 CDD:410632 4/29 (14%)
TM helix 6 422..449 CDD:410632 6/26 (23%)
TM helix 7 457..482 CDD:410632 8/27 (30%)
ADGRF5XP_005248949.1 SEA 179..281 CDD:470595
IG_like 285..361 CDD:214653
Ig strand B 289..293 CDD:409353
Ig strand C 301..305 CDD:409353
Ig strand E 333..337 CDD:409353
Ig strand F 347..351 CDD:409353
IG_like 517..602 CDD:214653
GPS 993..1036 CDD:460350 6/27 (22%)
7tmB2_GPR116_Ig-Hepta 1049..1323 CDD:320382 58/314 (18%)
TM helix 1 1051..1076 CDD:320382 6/26 (23%)
TM helix 2 1091..1113 CDD:320382 3/21 (14%)
TM helix 3 1127..1150 CDD:320382 5/22 (23%)
TM helix 4 1170..1186 CDD:320382 0/15 (0%)
TM helix 5 1208..1231 CDD:320382 5/47 (11%)
TM helix 6 1255..1280 CDD:320382 7/30 (23%)
TM helix 7 1285..1310 CDD:320382 8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

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