DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl7 and ADGRF5

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_005248949.1	Gene:	ADGRF5 / 221395	HGNCID:	19030	Length:	1386	Species:	Homo sapiens

Alignment Length:	358	Identity:	67/358 - (18%)
Similarity:	118/358 - (32%)	Gaps:	120/358 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 WVTVDLFMEKQD----YCLYRH--NF------DSDFPKSMWIIRHRCTSHISPGSLEILIITMIC 232
            |.:...::|:.|    .|:..|  :|      ||..|.|:..|.....|::..| ..||.:. .|
Human  1008 WDSSGCYVEEGDGDNVTCICDHLTSFSILMSPDSPDPSSLLGILLDIISYVGVG-FSILSLA-AC 1070

  Fly   233 FVLTIAVYLYIKKLRN--VTGKCIV-----CCIVSRFIQCLIMILDHLNLL-NGICSPAGYSSHF 289
            .|:...|:..:.|.|.  :...|||     ..:.:.:...:..|.|:..:| ...|..|.:..||
Human  1071 LVVEAVVWKSVTKNRTSYMRHTCIVNIAASLLVANTWFIVVAAIQDNRYILCKTACVAATFFIHF 1135

  Fly   290 FRMASNLWLSVI---------------SYHTWKVLT--------------SLNRVDPNYRFLRYN 325
            |.::...|:..:               |..|.|.:.              :|....|...:.|.|
Human  1136 FYLSVFFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCLGYGCPLAISVITLGATQPREVYTRKN 1200

  Fly   326 AFVWSTAAIMTGSIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVA 390
            . .|..              ||:..:      |:.|                :.|:|.:...|:
Human  1201 V-CWLN--------------WEDTKA------LLAF----------------AIPALIIVVVNI- 1227

  Fly   391 MFALTAIYIRKV-KGGINKFTNEEEGRINCINFDSQTYLQFLR----LSIVMGLTWIFNVIPYSA 450
              .:|.:.|.|: :..|.....::|         ..:..|..:    |:.::||||.|.:.....
Human  1228 --TITIVVITKILRPSIGDKPCKQE---------KSSLFQISKSIGVLTPLLGLTWGFGLTTVFP 1281

  Fly   451 RLHIFWEWVGIISEYFHSAFGIV-----LFVLL 478
            ..::          .||..|.|:     ||:||
Human  1282 GTNL----------VFHIIFAILNVFQGLFILL 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	11/45 (24%)
ADGRF5	XP_005248949.1	SEA	170..259	CDD:279699
		IG_like	285..361	CDD:214653
		IGc2	285..351	CDD:197706
		IG_like	517..602	CDD:214653
		GPS	994..1036	CDD:280071	6/27 (22%)
		7tm_4	1051..1302	CDD:304433	53/311 (17%)
		7tm_1	1070..1308	CDD:278431	52/294 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810