DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl7 and ADGRE1

DIOPT Version :9

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:XP_011526096.1 Gene:ADGRE1 / 2015 HGNCID:3336 Length:978 Species:Homo sapiens


Alignment Length:371 Identity:73/371 - (19%)
Similarity:139/371 - (37%) Gaps:109/371 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 YFLEEVS-IQIFNKCGLIVWFQD--GKFWVTVD--LFMEKQDYCLYRHN-------------FDS 201
            |.||.:. .|.|.:...:.|..|  |..|.:..  :....:.|.:...|             ...
Human   626 YTLENIQPKQKFERPICVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTM 690

  Fly   202 DFPKSMWIIRHRCTSHISPGSLEILIITMICFVLTIAVYLYIKKLRNVTGKCIVCCIVSRFIQ-- 264
            ||  |::||     ||:.      :||:::|.||.||.:|..:.:||          .:.::.  
Human   691 DF--SLYII-----SHVG------IIISLVCLVLAIATFLLCRSIRN----------HNTYLHLH 732

  Fly   265 -CLIMILDHLNLLNGI--------CSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVD---- 316
             |:.::|.....|.||        |:......|:..:|...|:.|.:...:.::.:|..|:    
Human   733 LCVCLLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLACFFWMLVEAVILFLMVRNLKVVNYFSS 797

  Fly   317 PNYRFLRYNAF--------VWSTAAIMTGSIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSV 373
            .|.:.|...||        |..:|::......:.|:.|.|..:        |||           
Human   798 RNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHNRCWLNTET--------GFI----------- 843

  Fly   374 WIYISGPSLALSTFNVAMFALTAIYIRKVKGGIN-KFTNEEEGRINCINFDSQTYLQFLRLSIVM 437
            |.:: ||...:...|..:...|...:|:....:| :.:..::.|:       .|:..|.:| .::
Human   844 WSFL-GPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRL-------LTFKAFAQL-FIL 899

  Fly   438 GLTW---IFNVIPYSARLHIFWEWVGIISEYF---HSAFGIVLFVL 477
            |.:|   ||.:.|.:          |:::..|   :|..|..:|::
Human   900 GCSWVLGIFQIGPVA----------GVMAYLFTIINSLQGAFIFLI 935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:299804 16/76 (21%)
ADGRE1XP_011526096.1 EGF_CA 33..62 CDD:238011
EGF_CA 80..114 CDD:214542
EGF_CA 132..171 CDD:214542
EGF_CA 172..206 CDD:214542
EGF_CA 224..260 CDD:214542
EGF_CA 264..297 CDD:214542
EGF_CA 313..>342 CDD:214542
EGF_CA 360..400 CDD:284955
GPS 638..687 CDD:197639 6/48 (13%)
7tm_2 691..932 CDD:278432 61/301 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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