DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and lat-1

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001366731.1	Gene:	lat-1 / 174419	WormBaseID:	WBGene00002251	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	273	Identity:	60/273 - (21%)
Similarity:	106/273 - (38%)	Gaps:	57/273 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 IITMICFVLTIAVYLYIKKLRNVTGKCIVCCIVSR------FIQ---CLIMILDHLNLLNGI--- 279
            ||::||.:||...||                |.||      ||.   ||.:.:..:..|.||
Worm   560 IISIICLLLTFFAYL----------------IFSRNGGDRVFIHENLCLSLAIAEITFLAGITRT 608

  Fly   280 -----CSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNAFVWSTAAIMTGSI 339
                 |.....:..:..:::..|:.:..||..::||.:...||  |...|....:...||:|...
Worm   609 EDSLQCGIIAVALMYMFLSALTWMLLEGYHIHRMLTEVFPSDP--RRFTYLLVGYIPPAIITLVA 671

  Fly   340 YIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFN--VAMFALTAIYIRKV 402
            |:.|......|.           .|.:...:..:| :.:||:..:...|  |.:..|..:| :..
Worm   672 YLYNSDGFGTPD-----------HCWLSTQNNFIW-FFAGPACFIFCANSLVLVKTLCTVY-QHT 723

  Fly   403 KGGINKFTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSARLHIFWEWVGIISEYFH 467
            .||.....::.:...:..|:...:    |.|:.::|:||||.:........|...:|..||   :
Worm   724 SGGYLPCRHDVDSGRSIRNWVKGS----LALASLLGVTWIFGLFWVEDSRSIVMAYVFTIS---N 781

  Fly   468 SAFGIVLFVLLVL 480
            |..|:.:|:..|:
Worm   782 SLQGLFIFLFHVV 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804
lat-1	NP_001366731.1	Gal_Lectin	51..133	CDD:396628
		HormR	180..244	CDD:214468
		GAIN	258..462	CDD:406802
		GPS	493..541	CDD:197639
		7tmB2_latrophilin-like_invertebrate	548..808	CDD:320556	60/273 (22%)
		TM helix 1	551..575	CDD:320556	8/30 (27%)
		TM helix 2	584..605	CDD:320556	5/20 (25%)
		TM helix 3	615..637	CDD:320556	1/21 (5%)
		TM helix 4	655..671	CDD:320556	4/15 (27%)
		TM helix 5	690..713	CDD:320556	5/23 (22%)
		TM helix 6	744..766	CDD:320556	7/25 (28%)
		TM helix 7	771..796	CDD:320556	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910