DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl7 and Adgrl2

DIOPT Version :9

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:409 Identity:74/409 - (18%)
Similarity:136/409 - (33%) Gaps:124/409 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 ARVPLTDMAIIRDEFFDCDEMIYISDFNYFLEEVSIQIFNKCGLI-VWFQDGKFWVTVDLFMEKQ 190
            :||.|||..:.        .|.:|...|||....|...:::..:: .|...|...|..:   :.:
  Rat   767 SRVYLTDPVLF--------SMPHIDSDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTN---KTR 820

  Fly   191 DYCLYRH--NFDSDFPKSMWIIRHRCTSHISPGSLEI------------------LIITMICFVL 235
            ..|...|  ||       ..::.||          ||                  ::::::|..:
  Rat   821 TTCACSHLTNF-------AILMAHR----------EIVYKDGVHKLLLTVITWVGIVVSLVCLAI 868

  Fly   236 TIAVYLYIKKL---RNVTGKCIVCCIVSRFIQCLIMILDHLNLLNGI--------CSPAGYSSHF 289
            .|..:.:.:.|   ||...|.:          |:.:.:.....|.||        |.......||
  Rat   869 CIFTFCFFRGLQSDRNTIHKNL----------CINLFIAEFIFLIGIDKTQYTIACPVFAGLLHF 923

  Fly   290 FRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNAFVWSTAAIMTGSIYIVNQIWENDPSKWN 354
            |.:|:..|:.:.....:.:|..:...:.:.:...|.|.....|.::..|..|       |...:.
  Rat   924 FFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAI-------DYKSYG 981

  Fly   355 -----WLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAIYIRK----VKGGINKFT 410
                 ||.:..:.          :|.:| ||...:...|:....:|...:.|    :|...::..
  Rat   982 TLEACWLHVDNYF----------IWSFI-GPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLE 1035

  Fly   411 NEEEGRINC---INFDSQTY-----------LQFLRLSIVMGLTWIFNVIPYSARLHIFWEWVGI 461
            |....|: |   .|.|...|           |....|..::||||.|.:        :|.....:
  Rat  1036 NINNYRV-CDGYYNTDLPGYEDNKPFIKSWVLGAFALLCLLGLTWSFGL--------LFVNEETV 1091

  Fly   462 ISEYFHSAF----GIVLFV 476
            :..|..:||    |:.:|:
  Rat  1092 VMAYLFTAFNAFQGLFIFI 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:299804 19/89 (21%)
Adgrl2NP_599235.3 Gal_Lectin 49..129 CDD:396628
OLF 142..398 CDD:413369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462
HormR 469..533 CDD:214468
GAIN 542..764 CDD:406802
GPS 788..840 CDD:197639 11/71 (15%)
7tm_GPCRs 848..1129 CDD:421689 52/300 (17%)
TM helix 1 850..875 CDD:410628 2/24 (8%)
TM helix 2 884..906 CDD:410628 5/31 (16%)
TM helix 3 915..942 CDD:410628 5/26 (19%)
TM helix 4 954..974 CDD:410628 4/19 (21%)
TM helix 5 991..1020 CDD:410628 6/39 (15%)
TM helix 6 1036..1087 CDD:410628 14/59 (24%)
TM helix 7 1091..1116 CDD:410628 5/20 (25%)
Latrophilin 1128..1487 CDD:396778
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.