DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl7 and Adgrl4

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_573485.2	Gene:	Adgrl4 / 170757	MGIID:	2655562	Length:	739	Species:	Mus musculus

Alignment Length:	482	Identity:	91/482 - (18%)
Similarity:	168/482 - (34%)	Gaps:	153/482 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DGSITPIEKHLRA-------------CVCSVRPCIRICCPAKNFLANGKCDDG----------LK 108
            ||....|....:|             |..|:.|   :...:.|||.:.:.|:.          :.
Mouse   324 DGGYVKISPRRKAAHGTTGNVVVAFLCYKSIGP---LLSSSDNFLLDTQNDNSEGKEKVISSVIS 385

  Fly   109 EELARFKPYIY------FTYMDLQARVPLTDMAIIRDEFFDCDEMIYISDFNYFLEEVSIQIFNK 167
            ..::...|.:|      ||.    :.|.|:|....:..|           :||     |:...|.
Mouse   386 ASISSNPPTLYELEKITFTL----SHVKLSDKHRTQCAF-----------WNY-----SVDAMNN 430

  Fly   168 CGLIVWFQDGKFWVTVDLFMEKQDYCLYRHNFDSDFPKSMWIIRH---RCTSHI--------SPG 221
            ..   |..:|               |...|:.|:          |   || ||:        |..
Mouse   431 GS---WSTEG---------------CELTHSNDT----------HTSCRC-SHLTHFAILMSSTS 466

  Fly   222 SLEI-------------LIITMICFVLTIAVYLYIKKLRNVTGKCI---VCCIVSRFIQCLIMIL 270
            |:.|             :||::||..:.|..:.:..:::: |...|   :||  |.|:..|:.::
Mouse   467 SIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQS-TRTTIHKNLCC--SLFLAELVFLI 528

  Fly   271 D-HLNLLNGICSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNAFVWS--TA 332
            . ::|....:||......|:|.:|:..|:.:...|.:.::..   |..|..||..|.:::.  :.
Mouse   529 GININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVG---VIYNKGFLHKNFYIFGYLSP 590

  Fly   333 AIMTG-------SIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVA 390
            |::.|       ..|...::                  |.:...:..:|.:| ||:..:...|:.
Mouse   591 AVVVGFSASLGYRYYGTTKV------------------CWLSTENNFIWSFI-GPACLIILVNLL 636

  Fly   391 MFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSARLHIF 455
            .|.:....:.:...|:       :..::|...........|.|..::|.||||.|: :.....:.
Mouse   637 AFGVIIYKVFRHTAGL-------KPEVSCYENIRSCARGALALLFLLGTTWIFGVL-HVVHASVV 693

  Fly   456 WEWVGIISEYFHSAFGIVLFVLLVLKR 482
            ..::..:|..|...| |.|| |.||.|
Mouse   694 TAYLFTVSNAFQGMF-IFLF-LCVLSR 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	29/178 (16%)
Adgrl4	NP_573485.2	EGF_CA	58..91	CDD:214542
		EGF_CA	108..141	CDD:214542
		GAIN	190..370	CDD:293098	10/48 (21%)
		GPS	417..461	CDD:280071	15/88 (17%)
		7tm_4	473..709	CDD:304433	48/269 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810