Protein Alignment mthl7 and mthl11

DIOPT Version :10

• Sequence 1: NP_648181.2
• Gene: mthl7 / 38910
• FlyBaseID: FBgn0035847
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 145/495 - (29%)
• Similarity: 231/495 - (46%)
• Gaps: 70/495 - (14%)

  Fly    23 DIPGCNYYDTVDISYIERQ-NDSYLYDDIEIPASLTGYYEFRQFGDGSITPIEKHLRACVCSVRP 86
            |||.|:::|||.:...|:. |.||.|:|:.|||.|||.|::....||....:.||:|.|||.::.
  Fly    22 DIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSVPKHIRGCVCKLKT 86

  Fly    87 CIRICCPAKNFLANGKCDDGLKEELARFKPYIY---FTYMD---LQARVPLTDMAIIRDEFFDCD 145
            |||.||..|..:|...|...:.|.|.    |.|   .|.::   ::..| |.||.:.:|....|:
  Fly    87 CIRFCCHHKKLMAGNLCSQDVYENLT----YEYTLDITQLNGSVIKKHV-LNDMVVQQDLPLPCE 146

  Fly   146 EMIYISDFNYFLE-EVSIQIFNKCGLIVW--FQDGKFWVTVD-LFMEKQDYCLYRHNFDSDFPKS 206
            .       :|.|: |.|.       ..:|  :::|..:...| .::.||::|| :.|..|.....
  Fly   147 R-------HYSLDAETST-------YDMWSLYENGSLFRHFDQRYLSKQEFCL-QPNPTSTGKNY 196

  Fly   207 MWIIRHRC-----------------TSHISPGSLEILIITMICFVLTIAVYLYIKKLRNVTGKCI 254
            ..|:...|                 .|.:|..|:.:...::...|:|||.||::.|.|::.|||
  Fly   197 SLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKC- 260

  Fly   255 VC-----CIVSRFIQCLIMILDHLNLLNGICSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNR 314
             |     |:...|:..:|.:.....|...||...||:.:|..||:.|||||||:..|:.. ::.:
  Fly   261 -CNLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRF-AMRK 323

  Fly   315 VDPNYR-----FLRYNAFVWSTAAIMTGSIYIVNQIWE-NDPSKWNWLPLVGFIRCSV--KDWHP 371
            ....|:     |..||..|||:|.::|..|::|:|..| |..:.:|  |.||...|.:  ..|
  Fly   324 FQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYN--PAVGVFSCWIFTNGW-- 384

  Fly   372 SVWIYISGPSLALSTFNVAMFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQFLRLSIV 436
            |...|...|...|...|.|.|.||..||........|..|..|.:  .::.:...|..:.||.|:
  Fly   385 SATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQ--KLSRNHANYRIYFRLFII 447

  Fly   437 MGLTWIFNVIPYSARLHIFWEWVGIISEYFHSAFGIVLFV 476
            ||.:|...:|.:...:...|:.:.|:::|.:.:.||::||
  Fly   448 MGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFV 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:448329	58/197 (29%)
		7tmB3_Methuselah-like	226..489	CDD:410632	80/264 (30%)
		TM helix 2	251..271	CDD:410632	7/24 (29%)
		TM helix 3	281..308	CDD:410632	13/26 (50%)
		TM helix 4	321..341	CDD:410632	9/19 (47%)
		TM helix 5	369..399	CDD:410632	10/29 (34%)
		TM helix 6	422..449	CDD:410632	8/26 (31%)
		TM helix 7	457..482	CDD:410632	6/20 (30%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	58/197 (29%)
		7tmB3_Methuselah-like	236..504	CDD:410632	80/261 (31%)
		TM helix 2	258..280	CDD:410632	7/23 (30%)
		TM helix 3	291..318	CDD:410632	13/26 (50%)
		TM helix 4	335..355	CDD:410632	9/19 (47%)
		TM helix 5	383..412	CDD:410632	10/30 (33%)
		TM helix 6	433..460	CDD:410632	8/26 (31%)
		TM helix 7	468..493	CDD:410632	6/20 (30%)