DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl7 and adgrl2b.1

DIOPT Version :9

Sequence 1:	NP_648181.2	Gene:	mthl7 / 38910	FlyBaseID:	FBgn0035847	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001353776.1	Gene:	adgrl2b.1 / 110437953	ZFINID:	ZDB-GENE-130116-4	Length:	1454	Species:	Danio rerio

Alignment Length:	406	Identity:	85/406 - (20%)
Similarity:	155/406 - (38%)	Gaps:	94/406 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DDGLKEELARFKPYIYFTYMDLQ-ARVPLTDMAIIRDEFFDCDEMIYISDFNYFLEEVSIQIFNK 167
            |.||:........:|....::.: :||.:::..|...|..|.:        |||....|...:::
Zfish   725 DGGLRNHTLTVNSHILSASINKESSRVFVSEPVIFTLEHLDTE--------NYFNPNCSFWNYSE 781

  Fly   168 CGLIVWFQDGKFWVT--VDLFMEKQDY----CLYRHNFDSDFPKSMWIIRHRCTSHISPGSLEIL 226
            ..:      ..:|.|  ..|....:.:    |.:..||       ..::.|| .||...||:..|
Zfish   782 RSM------SGYWSTQGCKLLSTNKTHTTCSCSHLTNF-------AILMVHR-DSHAGEGSVHEL 832

  Fly   227 IIT----------MICFVLTIAVYLYIKKL---RNVTGKCIVCCIVSRFIQCLIMILDHLNLLNG 278
            ::|          ::|..::|..:.:.:.|   ||...|.:  || :.||..|:.::. :|:...
Zfish   833 LLTVITRLGIAVSLVCLAISIFTFCFFRGLQSDRNTIHKNL--CI-NLFIAELLFLVG-INMTEP 893

  Fly   279 --ICSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVDPNYRFLRYNA-------FVWSTAAI 334
              :||......|||.:|:..|:.:.....:.:|..:...:.:.|...|.:       .|..:|||
Zfish   894 PIVCSVIAGVLHFFFLAAFSWMCLEGVQLFLMLVEVFESEFSRRKYYYASGYLFPCVVVGISAAI 958

  Fly   335 MTGSIYIVNQIWENDPSKWNWLPLVGFIRCSVKDWHPSVWIYISGPSLALSTFNVAMFALTAIYI 399
            ...|.         ...|..||.:         |.| .:|.:| ||...:...|: :|.:..:|
Zfish   959 DYKSY---------GTKKACWLRV---------DNH-FIWSFI-GPVTFIILLNL-IFLVVTMY- 1001

  Fly   400 RKVKGGINKFTNEEEGRINCINFDSQTYLQFLRLSIVMGLTWIFNVIPYSARLHIFWEWVGIISE 464
            :.||..::  ...:..|:..|.  |..:..|..|.::. |||.|.:        :|.....:|..
Zfish  1002 KMVKHSMS--MKPDSSRLESIR--SWVFGAFALLCLLC-LTWSFGL--------LFLNDSSVIMA 1053

  Fly   465 YFHSAF----GIVLFV 476
            |..|.|    |:.:||
Zfish  1054 YLFSIFNTLQGMFIFV 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl7	NP_648181.2	Mth_Ecto	27..214	CDD:299804	20/116 (17%)
adgrl2b.1	NP_001353776.1	Gal_Lectin	50..130	CDD:307994
		OLF	139..395	CDD:321983
		HormR	468..528	CDD:214468
		GAIN	538..746	CDD:318649	4/20 (20%)
		GPS	770..822	CDD:197639	10/65 (15%)
		7tm_GPCRs	831..1088	CDD:333717	60/278 (22%)
		TM helix 1	834..858	CDD:320672	3/23 (13%)
		TM helix 2	867..888	CDD:320672	7/24 (29%)
		TM helix 3	898..920	CDD:320672	6/21 (29%)
		TM helix 4	939..955	CDD:320672	2/15 (13%)
		TM helix 5	974..997	CDD:320672	8/25 (32%)
		TM helix 6	1021..1046	CDD:320672	8/35 (23%)
		TM helix 7	1050..1075	CDD:320672	7/20 (35%)
		Latrophilin	1087..1454	CDD:308136
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900