DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl7 and ADGRG2

DIOPT Version :10

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:XP_047297711.1 Gene:ADGRG2 / 10149 HGNCID:4516 Length:1055 Species:Homo sapiens


Alignment Length:323 Identity:57/323 - (17%)
Similarity:120/323 - (37%) Gaps:84/323 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 CT-SHI-SPGSL-----------EILIITMICFV----------LTIAVYLYIKKL-RNVTGKCI 254
            || ||: |.|.|           :::.:|.|.::          :|:..|:..:|: |:...|.:
Human   639 CTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKIL 703

  Fly   255 VCCIVSRFIQCLIMILDH---LNLLNGICSPAGYSSHFFRMASNLWLSVISYHTWKVLTSLNRVD 316
            :....:..:..|:.:||.   |..:.|:|.......|:|.:.|..|:.:.::|.:..|..:....
Human   704 IQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTY 768

  Fly   317 PNYRFLRYNAFVWSTAAIMTGSIYIVN----------QIWENDPSKWNWLPLVGFIRCSVKDWHP 371
            .....|::....|...|::...|..::          :.....|..:.|:           :.:.
Human   769 IRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWI-----------NNNA 822

  Fly   372 SVWIYISGPSLALSTFNVAMFALTAIYIRKVKGGINKFTNEEEGRINCINFDSQTYLQFLR---- 432
            ..:|.:.|....:...||:||.:..:.:.::|            :...:....:|.:|.||    
Human   823 VFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK------------KKKQLGAQRKTSIQDLRSIAG 875

  Fly   433 LSIVMGLTWIFNVIPYSARLHIFWEW--VGIISEYFHSAF----GIVLFVLLVLK----RSTW 485
            |:.::|:||.|          .|:.|  |.:...|..:.|    |..:|:...:.    |..|
Human   876 LTFLLGITWGF----------AFFAWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQW 928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:448329 57/323 (18%)
7tmB3_Methuselah-like 226..489 CDD:410632 50/298 (17%)
TM helix 2 251..271 CDD:410632 2/19 (11%)
TM helix 3 281..308 CDD:410632 5/26 (19%)
TM helix 4 321..341 CDD:410632 4/19 (21%)
TM helix 5 369..399 CDD:410632 6/29 (21%)
TM helix 6 422..449 CDD:410632 9/30 (30%)
TM helix 7 457..482 CDD:410632 6/34 (18%)
ADGRG2XP_047297711.1 PHA03247 <285..458 CDD:223021
GPS 605..655 CDD:197639 7/15 (47%)
7tmB2_GPR64 663..932 CDD:320560 50/299 (17%)
TM helix 1 665..690 CDD:320560 4/24 (17%)
TM helix 2 700..722 CDD:320560 4/21 (19%)
TM helix 3 733..760 CDD:320560 5/26 (19%)
TM helix 4 775..791 CDD:320560 2/15 (13%)
TM helix 5 821..844 CDD:320560 5/22 (23%)
TM helix 6 867..892 CDD:320560 9/34 (26%)
TM helix 7 896..921 CDD:320560 4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

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