DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl7 and adgrf8

DIOPT Version :9

Sequence 1:NP_648181.2 Gene:mthl7 / 38910 FlyBaseID:FBgn0035847 Length:491 Species:Drosophila melanogaster
Sequence 2:XP_021324214.1 Gene:adgrf8 / 100537224 ZFINID:ZDB-GENE-130531-41 Length:1719 Species:Danio rerio


Alignment Length:360 Identity:64/360 - (17%)
Similarity:128/360 - (35%) Gaps:114/360 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 QIFNKCGLIVWFQDGKFWVTVDLFMEKQDYCLYRHNFDSDFPKSMWIIRHRCTSHISPGSLEILI 227
            |:.|..|:|.                    |...|........|.:|:.....::|:...:.|.:
Zfish  1358 QVGNDSGIIT--------------------CECNHTTSFSILMSPFILDSLILAYITYIGVTISM 1402

  Fly   228 ITMI-CFVLTIAVYLYIKKLRNVTGKCIVCCIVSRFIQCLIMILDHLNLLN-------------- 277
            |::: |.::...|:..:...|.||       :||.:::       |::|:|              
Zfish  1403 ISLVLCLIIEAIVWRSVTSARGVT-------VVSSYMR-------HISLVNIALSLLIANVCFII 1453

  Fly   278 -------------GICSPAGYSSHFFRMASNLWLSV----ISYHTWKVLTSLNRVDPNYRFLRYN 325
                         |.|||..:..|||.:|...|:.:    :.|.|..|...::|:    :.:..:
Zfish  1454 GAAISDLEKPTPVGRCSPVVFFIHFFYLAVFFWMLISGMLLLYMTVMVFGQMSRI----KMIAIS 1514

  Fly   326 AFVWSTAAIMTGSIYIVN----QIWENDPSKW-NW---LPLVGFIRCSVKDWHPSVWIYISGPSL 382
            ..|...|.::..||.:.:    |.:.:..:.| ||   ..|:.|:.                |:|
Zfish  1515 FPVGYGAPLLIASITVASTAGPQNYVSKQACWLNWNESRALLAFVI----------------PAL 1563

  Fly   383 ALSTFNVAMFALTAIYIRKVKGGINKFTNEEEGR-----INCINFDSQTYLQFLRLSIVMGLTWI 442
            .:...|:.:  |..:..:.:..|:...|...|..     :.|:.|          |:.:.||||.
Zfish  1564 TIVAINLVV--LVVVLYKMLGTGVGAATQPSEKNTFFVVVRCVAF----------LTPLFGLTWG 1616

  Fly   443 FNV---IPYSARLHIFWEWVGIISEYFHSAFGIVL 474
            |.:   :..:..:|:.:..:.....:|...||.:|
Zfish  1617 FGIGTMLSSALGVHVLFTLLNAFQGFFILLFGTIL 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl7NP_648181.2 Mth_Ecto 27..214 CDD:299804 8/50 (16%)
adgrf8XP_021324214.1 EGF_CA 156..189 CDD:214542
EGF_CA 324..357 CDD:214542
EGF_CA 508..>540 CDD:214542
EGF_CA 673..706 CDD:214542
Ig 899..968 CDD:325142
GPS 1337..1379 CDD:307782 6/40 (15%)
7tm_GPCRs 1387..1660 CDD:333717 56/311 (18%)
TM helix 1 1390..1414 CDD:320095 4/23 (17%)
TM helix 2 1434..1455 CDD:320095 3/20 (15%)
TM helix 3 1470..1492 CDD:320095 7/21 (33%)
TM helix 4 1513..1529 CDD:320095 3/15 (20%)
TM helix 5 1551..1574 CDD:320095 5/40 (13%)
TM helix 6 1598..1623 CDD:320095 8/34 (24%)
TM helix 7 1627..1652 CDD:320095 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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