DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmt and NMT2

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	XP_016872436.1	Gene:	NMT2 / 9397	HGNCID:	7858	Length:	502	Species:	Homo sapiens

Alignment Length:	494	Identity:	273/494 - (55%)
Similarity:	333/494 - (67%)	Gaps:	50/494 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGA----------------KNE-------A 62
            :|:.||:...:....|:.|||...:....|:.|...|:                |.|       .
Human     1 MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTK 65

  Fly    63 SVSANASKQ------------------------ALLQAVSDAMASTRQMAK-KFAFWSTQPVTKL 102
            |.||:.|::                        .||.|......:..:.|| ::.||.||||.||
Human    66 SDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKL 130

  Fly   103 DEQVTTNECIEPNKEISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNENYVEDDDAMFRFD 167
            ||.:|::..|||:|:  .:|..||:||.||.|.||||:||..|||||||||||||||||.|||||
Human   131 DEVITSHGAIEPDKD--NVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFD 193

  Fly   168 YQPEFLKWSLQPPGWKRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVDINFLCVHKKLRS 232
            |.||||.|:|:||||...||.||||..:.||||||||||:.::.||.|.|:|:||||||||||||
Human   194 YSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRS 258

  Fly   233 KRVAPVLIREITRRVNLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDVRFSHLARNMTMQ 297
            |||||||||||||||||.|||||.||||||||.|:||||||||||||:|||:|:||||:||||:|
Human   259 KRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQ 323

  Fly   298 RTMKLYKLPDQPKTKGYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHWFTPKEGIIDCFV 362
            ||||||:|||..||.|.|.:..||:....:|:..|||:|.|:||..:||..|||.|:|.|||.||
Human   324 RTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFV 388

  Fly   363 VADEKGNITDLTSYYCLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDALISARNVQMDVYN 427
            |....|.:||..|:|.|||:|||||.||:::|||||||:.|:||.||||:||||.|::...||:|
Human   389 VESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFN 453

  Fly   428 ALDLMENKKYFAPLKFGAGDGNLQYYLYNWRCPSMQPEE 466
            ||||||||.:...||||.|||||||||||||||....|:
Human   454 ALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	115/155 (74%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	107/174 (61%)
NMT2	XP_016872436.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147521
Domainoid	1	1.000	247	1.000	Domainoid score	I2156
eggNOG	1	0.900	-	-		E1_COG5092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1182
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53825
OrthoDB	1	1.010	-	-		D1025421at2759
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm40585
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	O	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800