DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmt and NMT1

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_013296.1	Gene:	NMT1 / 850892	SGDID:	S000004185	Length:	455	Species:	Saccharomyces cerevisiae

Alignment Length:	413	Identity:	179/413 - (43%)
Similarity:	247/413 - (59%)	Gaps:	27/413 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LLQAVSDAMASTRQMAKK----FAFWSTQPVTKLDEQVTTNECIEPNKEISEIRALPYTLPGGFK 133
            |||..:|..:...|..||    ..||.||||...||:|.....|:..|...:|...|..|...|:
Yeast    16 LLQLNNDDTSKFTQEQKKAMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFE 80

  Fly   134 WVTLDLNDANDLKELYTLLNENYVEDDDAMFRFDYQPEFLKWSLQPPGWKRDWHVGVRVEKSGKL 198
            |.::|:::...|::::.|||||||||.||.|||:|..||..|:|:.||||:|||:||||:::.||
Yeast    81 WCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKL 145

  Fly   199 VGFISAIPSKLKSYDKVLKVVDINFLCVHKKLRSKRVAPVLIREITRRVNLTGIFQAAYTAGVVL 263
            |.||||||..|....|.:..|:||||||||:|||||:.||||:|||||||...|:.|.||||:||
Yeast   146 VAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVL 210

  Fly   264 PTPVATCRYWHRSLNPKKLVDVRFSHLARNMTMQRTMKLYKLPDQPKTKGYRRITAKDMDKAHKL 328
            |.||:||||.||.||.|||.:|.|:.|....|.:..:....||.:.||.|.|::..:|:|:..:|
Yeast   211 PAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFEL 275

  Fly   329 LEDYLKRFQLSPVFSKEEFRHWFTPKEG------IIDCFVVADEKGNITDLTSYYCLPSSVMHHP 387
            .:.|..||:|..:|:||||.|.|..:|.      :|..:||....|.|||..|:|.||.:::::.
Yeast   276 FKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLPFTILNNT 340

  Fly   388 VHKTVRAAYSFY-----------------NVSTKTPWLDLMNDALISARNVQMDVYNALDLMENK 435
            .:|.:...|.:|                 ..:.||...:|:.||.|.|:|..|||:|||...:|.
Yeast   341 KYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNT 405

  Fly   436 KYFAPLKFGAGDGNLQYYLYNWR 458
            .:...||||.|||.|.:||:|:|
Yeast   406 LFLDDLKFGPGDGFLNFYLFNYR 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	85/155 (55%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	66/198 (33%)
NMT1	NP_013296.1	NMT1	1..455	CDD:227423	179/413 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343909
Domainoid	1	1.000	186	1.000	Domainoid score	I670
eggNOG	1	0.900	-	-		E1_COG5092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I432
Isobase	1	0.950	-	0	Normalized mean entropy	S743
OMA	1	1.010	-	-		QHG53825
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		oto99161
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	LDO	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
TreeFam	1	0.960	-	-
	15	14.740