DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmt and nmt2

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_001186683.1	Gene:	nmt2 / 556483	ZFINID:	ZDB-GENE-030131-717	Length:	493	Species:	Danio rerio

Alignment Length:	484	Identity:	272/484 - (56%)
Similarity:	341/484 - (70%)	Gaps:	39/484 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NENAEDLSGQEL-------KQKAKEVADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGAKN 60
            ||:.:...|.:|       |||.|:         ||..:|    .|.|.:|:.:::.:.|
Zfish    33 NEHMQGSPGGDLGAKKKKKKQKRKK---------EKPSSG----GTKSDSASDSQEIKNP----- 79

  Fly    61 EASVSANASKQALLQAVSDAMASTRQMAK--------KFAFWSTQPVTKLDEQVTTNECIEPNKE 117
                :....|...:|...:.:::.:..||        |:.||.||||.||:|.|||:..|||:||
Zfish    80 ----AIPMQKLQDIQRAMELLSTCQGPAKNIDEATKHKYQFWDTQPVPKLNEVVTTHGPIEPDKE 140

  Fly   118 ISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNENYVEDDDAMFRFDYQPEFLKWSLQPPGW 182
              .||..||:||.||.|.||||::|..|||||||||||||||||.||||||.|.||||:|:||||
Zfish   141 --NIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDDNMFRFDYSPNFLKWALRPPGW 203

  Fly   183 KRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVDINFLCVHKKLRSKRVAPVLIREITRRV 247
            ...||.||||..:.||||||||||:.:..||.:.::|:|||||||||||||||||||||||||||
Zfish   204 LPHWHCGVRVSSNKKLVGFISAIPADIHIYDTLKRMVEINFLCVHKKLRSKRVAPVLIREITRRV 268

  Fly   248 NLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDVRFSHLARNMTMQRTMKLYKLPDQPKTK 312
            ||.|||||.||||||||.||:|||||||||||:|||:|:||||:||||:|||||||:|||..:|.
Zfish   269 NLEGIFQAVYTAGVVLPKPVSTCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDSTRTP 333

  Fly   313 GYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHWFTPKEGIIDCFVVADEKGNITDLTSYY 377
            |.|.:..:|:.:...||:.:|.:|.|.||..:||.:|||.|:|.|||.|||....|.:||..|:|
Zfish   334 GLRTMGDRDVKQVTALLQKHLSQFHLRPVMGEEEVKHWFLPQENIIDTFVVEGSGGMLTDFISFY 398

  Fly   378 CLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDALISARNVQMDVYNALDLMENKKYFAPLK 442
            .|||:|||||:||:::||||||||.|:||.:||||||||.|:....||:||||||:||.:...||
Zfish   399 TLPSTVMHHPLHKSLKAAYSFYNVHTETPLIDLMNDALILAKLKGFDVFNALDLMDNKNFLEKLK 463

  Fly   443 FGAGDGNLQYYLYNWRCPSMQPEEIALIL 471
            ||.||||||||||||:||.|.||::.|:|
Zfish   464 FGIGDGNLQYYLYNWKCPPMDPEKVGLVL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	114/155 (74%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	104/174 (60%)
nmt2	NP_001186683.1	NMT1	114..492	CDD:227423	251/379 (66%)
		NMT	134..289	CDD:279562	114/156 (73%)
		NMT_C	305..480	CDD:280893	104/174 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581259
Domainoid	1	1.000	245	1.000	Domainoid score	I2146
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1148
OMA	1	1.010	-	-		QHG53825
OrthoDB	1	1.010	-	-		D1025421at2759
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm26452
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	O	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.900